Polymicrobial interactions

Impact on pathogenesis and human disease

Brian Peters, Mary Ann Jabra-Rizk, Graeme A. O'May, J. William Costerton, Mark E. Shirtliff

Research output: Contribution to journalReview article

241 Citations (Scopus)

Abstract

Microorganisms coexist in a complex milieu of bacteria, fungi, archaea, and viruses on or within the human body, often as multifaceted polymicrobial biofilm communities at mucosal sites and on abiotic surfaces. Only recently have we begun to appreciate the complicated biofilm phenotype during infection; moreover, even less is known about the interactions that occur between microorganisms during polymicrobial growth and their implications in human disease. Therefore, this review focuses on polymicrobial biofilm-mediated infections and examines the contribution of bacterial-bacterial, bacterial-fungal, and bacterial-viral interactions during human infection and potential strategies for protection against such diseases.

Original languageEnglish (US)
Pages (from-to)193-213
Number of pages21
JournalClinical Microbiology Reviews
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2012

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Biofilms
Infection
Archaea
Human Body
Fungi
Viruses
Bacteria
Phenotype
Growth

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Immunology and Microbiology(all)
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Peters, B., Jabra-Rizk, M. A., O'May, G. A., William Costerton, J., & Shirtliff, M. E. (2012). Polymicrobial interactions: Impact on pathogenesis and human disease. Clinical Microbiology Reviews, 25(1), 193-213. https://doi.org/10.1128/CMR.00013-11

Polymicrobial interactions : Impact on pathogenesis and human disease. / Peters, Brian; Jabra-Rizk, Mary Ann; O'May, Graeme A.; William Costerton, J.; Shirtliff, Mark E.

In: Clinical Microbiology Reviews, Vol. 25, No. 1, 01.01.2012, p. 193-213.

Research output: Contribution to journalReview article

Peters, B, Jabra-Rizk, MA, O'May, GA, William Costerton, J & Shirtliff, ME 2012, 'Polymicrobial interactions: Impact on pathogenesis and human disease', Clinical Microbiology Reviews, vol. 25, no. 1, pp. 193-213. https://doi.org/10.1128/CMR.00013-11
Peters, Brian ; Jabra-Rizk, Mary Ann ; O'May, Graeme A. ; William Costerton, J. ; Shirtliff, Mark E. / Polymicrobial interactions : Impact on pathogenesis and human disease. In: Clinical Microbiology Reviews. 2012 ; Vol. 25, No. 1. pp. 193-213.
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