Polymorphisms of ACE2 are associated with blood pressure response to cold pressor test

The gensalt study

Jianfeng Huang, Shufeng Chen, Xiangfeng Lu, Qi Zhao, Dabeeru C. Rao, Cashell E. Jaquish, James E. Hixson, Jichun Chen, Laiyuan Wang, Jie Cao, Jianxin Li, Hongfan Li, Jiang He, De Pei Liu, Dongfeng Gu

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Background Increased blood pressure (BP) reactivity to cold pressor test (CPT) is a risk factor for hypertension. Genetic factors may influence the variation of BP response to CPT among individuals. We explored the association of genetic variants in the apelin system genes (APLN, APLNR and ACE2) and BP response to CPT in a Chinese population. Methods A total of 1,998 Han Chinese participants from the Genetic Epidemiology Network of Salt Sensitivity completed a CPT. The percentage changes of BP right after the end of ice-water immersion were used as the measurement of BP responses to CPT. Twenty-two single nucleotide polymorphisms (SNPs) were selected and genotyped, including both tag and potential functional SNPs of the APLN, APLNR, and ACE2 genes. A mixed-effect linear model was used to assess the association between SNPs and BP responses to CPT. Results In women, three SNPs (rs1514283, rs4646176, and rs879922) of the ACE2 gene were significantly associated with the diastolic BP (DBP) response to CPT in the general and recessive genetic models after adjustment for multiple testing (all false discovery rate q>0.05). There were no significant associations of polymorphisms in APLN and APLNR genes with BP responses to CPT. Conclusions Our study identified genetic variants in the ACE2 gene that were significantly associated with DBP responses to cold stress in the Chinese female population. Future studies are warranted to confirm these findings.

Original languageEnglish (US)
Pages (from-to)937-942
Number of pages6
JournalAmerican journal of hypertension
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Fingerprint

Blood Pressure
Single Nucleotide Polymorphism
Genes
Cold-Shock Response
Molecular Epidemiology
Genetic Models
Ice
Immersion
Population
Linear Models
Salts
Hypertension
Water

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Polymorphisms of ACE2 are associated with blood pressure response to cold pressor test : The gensalt study. / Huang, Jianfeng; Chen, Shufeng; Lu, Xiangfeng; Zhao, Qi; Rao, Dabeeru C.; Jaquish, Cashell E.; Hixson, James E.; Chen, Jichun; Wang, Laiyuan; Cao, Jie; Li, Jianxin; Li, Hongfan; He, Jiang; Liu, De Pei; Gu, Dongfeng.

In: American journal of hypertension, Vol. 25, No. 8, 01.08.2012, p. 937-942.

Research output: Contribution to journalReview article

Huang, J, Chen, S, Lu, X, Zhao, Q, Rao, DC, Jaquish, CE, Hixson, JE, Chen, J, Wang, L, Cao, J, Li, J, Li, H, He, J, Liu, DP & Gu, D 2012, 'Polymorphisms of ACE2 are associated with blood pressure response to cold pressor test: The gensalt study', American journal of hypertension, vol. 25, no. 8, pp. 937-942. https://doi.org/10.1038/ajh.2012.61
Huang, Jianfeng ; Chen, Shufeng ; Lu, Xiangfeng ; Zhao, Qi ; Rao, Dabeeru C. ; Jaquish, Cashell E. ; Hixson, James E. ; Chen, Jichun ; Wang, Laiyuan ; Cao, Jie ; Li, Jianxin ; Li, Hongfan ; He, Jiang ; Liu, De Pei ; Gu, Dongfeng. / Polymorphisms of ACE2 are associated with blood pressure response to cold pressor test : The gensalt study. In: American journal of hypertension. 2012 ; Vol. 25, No. 8. pp. 937-942.
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abstract = "Background Increased blood pressure (BP) reactivity to cold pressor test (CPT) is a risk factor for hypertension. Genetic factors may influence the variation of BP response to CPT among individuals. We explored the association of genetic variants in the apelin system genes (APLN, APLNR and ACE2) and BP response to CPT in a Chinese population. Methods A total of 1,998 Han Chinese participants from the Genetic Epidemiology Network of Salt Sensitivity completed a CPT. The percentage changes of BP right after the end of ice-water immersion were used as the measurement of BP responses to CPT. Twenty-two single nucleotide polymorphisms (SNPs) were selected and genotyped, including both tag and potential functional SNPs of the APLN, APLNR, and ACE2 genes. A mixed-effect linear model was used to assess the association between SNPs and BP responses to CPT. Results In women, three SNPs (rs1514283, rs4646176, and rs879922) of the ACE2 gene were significantly associated with the diastolic BP (DBP) response to CPT in the general and recessive genetic models after adjustment for multiple testing (all false discovery rate q>0.05). There were no significant associations of polymorphisms in APLN and APLNR genes with BP responses to CPT. Conclusions Our study identified genetic variants in the ACE2 gene that were significantly associated with DBP responses to cold stress in the Chinese female population. Future studies are warranted to confirm these findings.",
author = "Jianfeng Huang and Shufeng Chen and Xiangfeng Lu and Qi Zhao and Rao, {Dabeeru C.} and Jaquish, {Cashell E.} and Hixson, {James E.} and Jichun Chen and Laiyuan Wang and Jie Cao and Jianxin Li and Hongfan Li and Jiang He and Liu, {De Pei} and Dongfeng Gu",
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T1 - Polymorphisms of ACE2 are associated with blood pressure response to cold pressor test

T2 - The gensalt study

AU - Huang, Jianfeng

AU - Chen, Shufeng

AU - Lu, Xiangfeng

AU - Zhao, Qi

AU - Rao, Dabeeru C.

AU - Jaquish, Cashell E.

AU - Hixson, James E.

AU - Chen, Jichun

AU - Wang, Laiyuan

AU - Cao, Jie

AU - Li, Jianxin

AU - Li, Hongfan

AU - He, Jiang

AU - Liu, De Pei

AU - Gu, Dongfeng

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Background Increased blood pressure (BP) reactivity to cold pressor test (CPT) is a risk factor for hypertension. Genetic factors may influence the variation of BP response to CPT among individuals. We explored the association of genetic variants in the apelin system genes (APLN, APLNR and ACE2) and BP response to CPT in a Chinese population. Methods A total of 1,998 Han Chinese participants from the Genetic Epidemiology Network of Salt Sensitivity completed a CPT. The percentage changes of BP right after the end of ice-water immersion were used as the measurement of BP responses to CPT. Twenty-two single nucleotide polymorphisms (SNPs) were selected and genotyped, including both tag and potential functional SNPs of the APLN, APLNR, and ACE2 genes. A mixed-effect linear model was used to assess the association between SNPs and BP responses to CPT. Results In women, three SNPs (rs1514283, rs4646176, and rs879922) of the ACE2 gene were significantly associated with the diastolic BP (DBP) response to CPT in the general and recessive genetic models after adjustment for multiple testing (all false discovery rate q>0.05). There were no significant associations of polymorphisms in APLN and APLNR genes with BP responses to CPT. Conclusions Our study identified genetic variants in the ACE2 gene that were significantly associated with DBP responses to cold stress in the Chinese female population. Future studies are warranted to confirm these findings.

AB - Background Increased blood pressure (BP) reactivity to cold pressor test (CPT) is a risk factor for hypertension. Genetic factors may influence the variation of BP response to CPT among individuals. We explored the association of genetic variants in the apelin system genes (APLN, APLNR and ACE2) and BP response to CPT in a Chinese population. Methods A total of 1,998 Han Chinese participants from the Genetic Epidemiology Network of Salt Sensitivity completed a CPT. The percentage changes of BP right after the end of ice-water immersion were used as the measurement of BP responses to CPT. Twenty-two single nucleotide polymorphisms (SNPs) were selected and genotyped, including both tag and potential functional SNPs of the APLN, APLNR, and ACE2 genes. A mixed-effect linear model was used to assess the association between SNPs and BP responses to CPT. Results In women, three SNPs (rs1514283, rs4646176, and rs879922) of the ACE2 gene were significantly associated with the diastolic BP (DBP) response to CPT in the general and recessive genetic models after adjustment for multiple testing (all false discovery rate q>0.05). There were no significant associations of polymorphisms in APLN and APLNR genes with BP responses to CPT. Conclusions Our study identified genetic variants in the ACE2 gene that were significantly associated with DBP responses to cold stress in the Chinese female population. Future studies are warranted to confirm these findings.

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