Polyneuropathy in juvenile dermatomyositis

S. A. Vogelgesang, J. Gutierrez, Gary Klipple, I. M. Katona

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We describe 2 patients in whom juvenile dermatomyositis (DM) was associated with well defined clinical polyneuropathies, and review the clinical and serological data. Light and electron microscopy were used to study muscle and nerve tissues from one patient. Neuropathy in our patients was associated with ulcerative skin lesions and elevated serum levels of factor VIII related antigen. Light microscopic studies of muscle revealed perifascicular atrophy and microinfarcts consistent with juvenile DM. Light microscopy of the affected sural nerve showed axonal degeneration. Electron microscopy of the same nerve demonstrated capillary endothelial inclusions characteristic of those observed as manifestations of early endothelial injury in juvenile DM muscle tissue. Polyneuropathy in patients with juvenile DM is a rare complication and is likely due to ischemia secondary to endothelial damage.

Original languageEnglish (US)
Pages (from-to)1369-1372
Number of pages4
JournalJournal of Rheumatology
Volume22
Issue number7
StatePublished - Jan 1 1995
Externally publishedYes

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Polyneuropathies
Light
Muscles
Electron Microscopy
Nerve Tissue
Sural Nerve
von Willebrand Factor
Atrophy
Microscopy
Ischemia
Skin
Juvenile dermatomyositis
Wounds and Injuries
Serum

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Vogelgesang, S. A., Gutierrez, J., Klipple, G., & Katona, I. M. (1995). Polyneuropathy in juvenile dermatomyositis. Journal of Rheumatology, 22(7), 1369-1372.

Polyneuropathy in juvenile dermatomyositis. / Vogelgesang, S. A.; Gutierrez, J.; Klipple, Gary; Katona, I. M.

In: Journal of Rheumatology, Vol. 22, No. 7, 01.01.1995, p. 1369-1372.

Research output: Contribution to journalArticle

Vogelgesang, SA, Gutierrez, J, Klipple, G & Katona, IM 1995, 'Polyneuropathy in juvenile dermatomyositis', Journal of Rheumatology, vol. 22, no. 7, pp. 1369-1372.
Vogelgesang SA, Gutierrez J, Klipple G, Katona IM. Polyneuropathy in juvenile dermatomyositis. Journal of Rheumatology. 1995 Jan 1;22(7):1369-1372.
Vogelgesang, S. A. ; Gutierrez, J. ; Klipple, Gary ; Katona, I. M. / Polyneuropathy in juvenile dermatomyositis. In: Journal of Rheumatology. 1995 ; Vol. 22, No. 7. pp. 1369-1372.
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