Positive Serum Screening for Fetal Down Syndrome Does Not Predict Adverse Pregnancy Outcome in Absence of Fetal Aneuploidy

Jeffrey S. Dungan, Lee P. Shulman, Owen Phillips, Joe Leigh Simpson, Norman Meyer, Chris Grevengood, Sherman Elias

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to determine whether false-positive maternal serum screening for fetal Down syndrome is predictive of poor pregnancy outcome. METHODS: The pregnancy outcomes of 99 women having positive serum screening for fetal Down syndrome (study group)—based upon maternal serum alpha-fetoprotein (MSAFP), un conjugated estriol (uE3), hCG, and maternal age—were compared to the outcomes of matched control patients having negative serum screening results (control group). The outcome indices analyzed were fetal death, intrauterine growth retardation (IUGR), preeclampsia, and fetal anomalies. RESULTS: Between the study group and the control group, there were no statistically significant differences in pregnancy outcome with respect to fetal death, IUGR, preeclampsia, or fetal anom alies. CONCLUSIONS: Our findings demonstrate no apparent increase in the adverse perinatal out comes analyzed in women having unexplained positive serum screening for fetal Down syndrome. Although further investigation is needed, these results provide no evidence to support increased antepartum surveillance in such patients. (J Soc Gynecol Invest 1994;1:55-8).

Original languageEnglish (US)
Pages (from-to)55-58
Number of pages4
JournalJournal of the Society for Gynecologic Investigation
Volume1
Issue number1
DOIs
StatePublished - Jan 1 1994

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Aneuploidy
Pregnancy Outcome
Down Syndrome
Serum
Fetal Death
Fetal Growth Retardation
Mothers
Pre-Eclampsia
Control Groups
Estriol
alpha-Fetoproteins

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Positive Serum Screening for Fetal Down Syndrome Does Not Predict Adverse Pregnancy Outcome in Absence of Fetal Aneuploidy. / Dungan, Jeffrey S.; Shulman, Lee P.; Phillips, Owen; Simpson, Joe Leigh; Meyer, Norman; Grevengood, Chris; Elias, Sherman.

In: Journal of the Society for Gynecologic Investigation, Vol. 1, No. 1, 01.01.1994, p. 55-58.

Research output: Contribution to journalArticle

Dungan, Jeffrey S. ; Shulman, Lee P. ; Phillips, Owen ; Simpson, Joe Leigh ; Meyer, Norman ; Grevengood, Chris ; Elias, Sherman. / Positive Serum Screening for Fetal Down Syndrome Does Not Predict Adverse Pregnancy Outcome in Absence of Fetal Aneuploidy. In: Journal of the Society for Gynecologic Investigation. 1994 ; Vol. 1, No. 1. pp. 55-58.
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abstract = "OBJECTIVE: The purpose of this study was to determine whether false-positive maternal serum screening for fetal Down syndrome is predictive of poor pregnancy outcome. METHODS: The pregnancy outcomes of 99 women having positive serum screening for fetal Down syndrome (study group)—based upon maternal serum alpha-fetoprotein (MSAFP), un conjugated estriol (uE3), hCG, and maternal age—were compared to the outcomes of matched control patients having negative serum screening results (control group). The outcome indices analyzed were fetal death, intrauterine growth retardation (IUGR), preeclampsia, and fetal anomalies. RESULTS: Between the study group and the control group, there were no statistically significant differences in pregnancy outcome with respect to fetal death, IUGR, preeclampsia, or fetal anom alies. CONCLUSIONS: Our findings demonstrate no apparent increase in the adverse perinatal out comes analyzed in women having unexplained positive serum screening for fetal Down syndrome. Although further investigation is needed, these results provide no evidence to support increased antepartum surveillance in such patients. (J Soc Gynecol Invest 1994;1:55-8).",
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