Positron Emission Tomography (PET) with 1-aminocyclobutane-1-[11C]carboxylic Acid (1-[11C]-ACBC) for detecting recurrent brain tumors

Karl Hubner, J. A. Thie, G. T. Smith, George Kabalka, I. B. Keller, A. B. Kliefoth, S. K. Campbell, E. Buonocore

Research output: Contribution to journalArticle

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Abstract

This study was done to determine whether 1-[11C]ACBC PET has any advantages over 2-[18F]FDG PET, CT, or MRI in detecting recurrent brain tumors, and whether quantitative 1-[11C]ACBC PET information improves the accuracy of "visual" image interpretation. Twenty patients with recurrent brain tumor underwent dynamic PET. Images were analyzed by visual interpretation; in addition, standardized uptake values (SUVs) and Patlak values (k1 *k3/k) were evaluated. 1-[11C]ACBC identified 19/20 recurrent brain tumors, [18F]FDG 13/19, MRI 13/19, and CT 8/16. Based on SUVs, the average tumor-to-contralateral gray matter ratio of 1-[11C]ACBC was 5.0 and 0.5 for 2-[18F]FDG. Mean Patlak values of 1-[11C]ACBC were 0.044 ± 0.047 for high and 0.034 ± 0.026 for low grade tumors. However, visual interpretation was effective without quantitative PET data. 1-[11C]ACBC, accurately detects recurrent tumors for selecting biopsy sites and treatment planning.

Original languageEnglish (US)
Pages (from-to)165-173
Number of pages9
JournalClinical Positron Imaging (Netherlands)
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1998

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Carboxylic Acids
Brain Neoplasms
Positron-Emission Tomography
Fluorodeoxyglucose F18
Neoplasms
Biopsy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Positron Emission Tomography (PET) with 1-aminocyclobutane-1-[11C]carboxylic Acid (1-[11C]-ACBC) for detecting recurrent brain tumors. / Hubner, Karl; Thie, J. A.; Smith, G. T.; Kabalka, George; Keller, I. B.; Kliefoth, A. B.; Campbell, S. K.; Buonocore, E.

In: Clinical Positron Imaging (Netherlands), Vol. 1, No. 3, 01.01.1998, p. 165-173.

Research output: Contribution to journalArticle

Hubner, Karl ; Thie, J. A. ; Smith, G. T. ; Kabalka, George ; Keller, I. B. ; Kliefoth, A. B. ; Campbell, S. K. ; Buonocore, E. / Positron Emission Tomography (PET) with 1-aminocyclobutane-1-[11C]carboxylic Acid (1-[11C]-ACBC) for detecting recurrent brain tumors. In: Clinical Positron Imaging (Netherlands). 1998 ; Vol. 1, No. 3. pp. 165-173.
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