Possible failure of NADP-glutamate dehydrogenase to participate directly in nitrogen repression of the allantoin degradative enzymes in Saccharomyces cerevisiae

June Bossinger, Terrance Cooper

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The extent of repression exerted by various nitrogen-containing compounds was measured in wild type and NADP-GDH defective strains of Saccharomyces. We found that in strains carrying the gdhA6- mutation, repression was relieved only for compounds whose metabolism involved the intermediate generation of ammonia. This raises the possibility that relief of repression observed in these strains is the result of their failure to effectively metabolize ammonia rather than an inability of the NADP-GDH protein to function as a regulator itself.

Original languageEnglish (US)
Pages (from-to)889-892
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume66
Issue number3
DOIs
StatePublished - Oct 6 1975
Externally publishedYes

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Glutamate Dehydrogenase (NADP+)
Allantoin
NADP
Ammonia
Yeast
Saccharomyces cerevisiae
Nitrogen
Nitrogen Compounds
Saccharomyces
Enzymes
Metabolism
Mutation
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

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abstract = "The extent of repression exerted by various nitrogen-containing compounds was measured in wild type and NADP-GDH defective strains of Saccharomyces. We found that in strains carrying the gdhA6- mutation, repression was relieved only for compounds whose metabolism involved the intermediate generation of ammonia. This raises the possibility that relief of repression observed in these strains is the result of their failure to effectively metabolize ammonia rather than an inability of the NADP-GDH protein to function as a regulator itself.",
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AU - Cooper, Terrance

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AB - The extent of repression exerted by various nitrogen-containing compounds was measured in wild type and NADP-GDH defective strains of Saccharomyces. We found that in strains carrying the gdhA6- mutation, repression was relieved only for compounds whose metabolism involved the intermediate generation of ammonia. This raises the possibility that relief of repression observed in these strains is the result of their failure to effectively metabolize ammonia rather than an inability of the NADP-GDH protein to function as a regulator itself.

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