Potent versus mild acid suppression in peptic ulcer disease

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In the consideration of potent versus mild suppression of gastric acid secretion in the treatment of peptic ulcer disease, it must be remembered that pharmacological effect in terms of degree of suppression of acidity is closely linked to therapeutic efficacy in terms of numbers of ulcers healed. More potent degrees of suppression of acidity result in faster ulcer healing. Moderate suppression of acidity, such as is achieved by the H2RA, can heal just as many ulcers if treatment is continued longer. Mild acid suppression will take still longer to produce the same healing rates. Therapeutic benefit of any treatment must be assessed also in terms of the side-effect profile of the drug or drugs used. There is an enormous cumulative experience with the H2RA as a group and they are known to have an excellent safety profile.

Original languageEnglish (US)
Pages (from-to)45-46
Number of pages2
JournalHepato-Gastroenterology
Volume39
Issue numberSUPPL. 1
StatePublished - 1992
Externally publishedYes

Fingerprint

Peptic Ulcer
Ulcer
Acids
Gastric Acid
Drug-Related Side Effects and Adverse Reactions
Pharmacology
Safety
Therapeutics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Potent versus mild acid suppression in peptic ulcer disease. / Howden, Colin.

In: Hepato-Gastroenterology, Vol. 39, No. SUPPL. 1, 1992, p. 45-46.

Research output: Contribution to journalArticle

@article{7771131012e541a5938305cdb674c6eb,
title = "Potent versus mild acid suppression in peptic ulcer disease",
abstract = "In the consideration of potent versus mild suppression of gastric acid secretion in the treatment of peptic ulcer disease, it must be remembered that pharmacological effect in terms of degree of suppression of acidity is closely linked to therapeutic efficacy in terms of numbers of ulcers healed. More potent degrees of suppression of acidity result in faster ulcer healing. Moderate suppression of acidity, such as is achieved by the H2RA, can heal just as many ulcers if treatment is continued longer. Mild acid suppression will take still longer to produce the same healing rates. Therapeutic benefit of any treatment must be assessed also in terms of the side-effect profile of the drug or drugs used. There is an enormous cumulative experience with the H2RA as a group and they are known to have an excellent safety profile.",
author = "Colin Howden",
year = "1992",
language = "English (US)",
volume = "39",
pages = "45--46",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Potent versus mild acid suppression in peptic ulcer disease

AU - Howden, Colin

PY - 1992

Y1 - 1992

N2 - In the consideration of potent versus mild suppression of gastric acid secretion in the treatment of peptic ulcer disease, it must be remembered that pharmacological effect in terms of degree of suppression of acidity is closely linked to therapeutic efficacy in terms of numbers of ulcers healed. More potent degrees of suppression of acidity result in faster ulcer healing. Moderate suppression of acidity, such as is achieved by the H2RA, can heal just as many ulcers if treatment is continued longer. Mild acid suppression will take still longer to produce the same healing rates. Therapeutic benefit of any treatment must be assessed also in terms of the side-effect profile of the drug or drugs used. There is an enormous cumulative experience with the H2RA as a group and they are known to have an excellent safety profile.

AB - In the consideration of potent versus mild suppression of gastric acid secretion in the treatment of peptic ulcer disease, it must be remembered that pharmacological effect in terms of degree of suppression of acidity is closely linked to therapeutic efficacy in terms of numbers of ulcers healed. More potent degrees of suppression of acidity result in faster ulcer healing. Moderate suppression of acidity, such as is achieved by the H2RA, can heal just as many ulcers if treatment is continued longer. Mild acid suppression will take still longer to produce the same healing rates. Therapeutic benefit of any treatment must be assessed also in terms of the side-effect profile of the drug or drugs used. There is an enormous cumulative experience with the H2RA as a group and they are known to have an excellent safety profile.

UR - http://www.scopus.com/inward/record.url?scp=0026596901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026596901&partnerID=8YFLogxK

M3 - Article

VL - 39

SP - 45

EP - 46

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - SUPPL. 1

ER -