Potential applications of nicotinic ligands in the laboratory and clinic

J. A. Dani, M. De Biasi, Y. Liang, J. Peterson, L. Zhang, T. Zhang, Fuming Zhou

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The nicotinic acetylcholine receptor (nAChR) is a receptor, ion channel complex composed of five polypeptide subunits. There are many different nAChR subtypes constructed from a variety of different subunit combinations. This structural diversity contributes to the varied roles of nAChRs in the peripheral and central nervous system, and this diversity offers an excellent opportunity for chemists who are producing ligands. Subunit specific ligands could have wide and varied effects in the laboratory as experimental tools and in the clinic as therapeutic agents. Because presynaptic nAChRs have been shown to enhance the release of many neurotransmitters, new nicotinic ligands that potentiate nAChR activity would be very useful. Such ligands could enhance the release of various neurotransmitters during degenerative diseases that cause neurotransmitter systems to decrease their output. For example, boosting the release from cholinergic neurons would help patients with Alzheimer's disease, and boosting the release from dopaminergic neurons would help patients with Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)1837-1839
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number8
DOIs
StatePublished - Apr 19 2004
Externally publishedYes

Fingerprint

Nicotinic Receptors
Ligands
Neurotransmitter Agents
Neurons
Cholinergic Neurons
Dopaminergic Neurons
Peripheral Nervous System
Neurology
Ion Channels
Cholinergic Agents
Parkinson Disease
Alzheimer Disease
Central Nervous System
Peptides
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Potential applications of nicotinic ligands in the laboratory and clinic. / Dani, J. A.; De Biasi, M.; Liang, Y.; Peterson, J.; Zhang, L.; Zhang, T.; Zhou, Fuming.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 8, 19.04.2004, p. 1837-1839.

Research output: Contribution to journalArticle

Dani, J. A. ; De Biasi, M. ; Liang, Y. ; Peterson, J. ; Zhang, L. ; Zhang, T. ; Zhou, Fuming. / Potential applications of nicotinic ligands in the laboratory and clinic. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 8. pp. 1837-1839.
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