Pre-B cell colony enhancing factor (PBEF), a cytokine with multiple physiological functions

Zhongjie Sun, Han Lei, Zhonge Zhang

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Pre-B cell colony enhancing factor (PBEF) is regarded as a proinflammatory cytokine. Named for its first discovered function as a pre-B cell colony enhancing factor, it has since been found to have many other functions relating to cell metabolism, inflammation, and immune modulation. It has also been found to have intracellular and extracellular forms, with the two overlapping in function. Most of the intracellular functions of PBEF are due to its role as a nicotinamide phosphoribosyltransferase (Nampt). It has been found in human endothelial cells, where it is able to induce angiogenesis through upregulation of VEGF and VEGFR and secretion of MCP-1. In human umbilical endothelial cells, PBEF increases levels of the protease MMP 2/9. PBEF has also been found in a variety of immune cells other than B cells and has been shown to inhibit apoptosis of macrophages. Extracellular PBEF has been shown to increase inflammatory cytokines, such as TNF-α, IL-1β, IL-16, and TGF-β1, and the chemokine receptor CCR3. PBEF also increases the production of IL-6, TNF-α, and IL-1β in CD14+ monocyctes, macrophages, and dendritic cells, enhances the effectiveness of T cells, and is vital to the development of both B and T lymphocytes. The purpose of this review is to summarize the recent advances in PBEF research.

Original languageEnglish (US)
Pages (from-to)433-442
Number of pages10
JournalCytokine and Growth Factor Reviews
Volume24
Issue number5
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

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Nicotinamide Phosphoribosyltransferase
Cytokines
T-cells
Macrophages
Endothelial cells
Interleukin-1
B-Lymphocytes
Endothelial Cells
Interleukin-16
T-Lymphocytes
Umbilicus
Chemokine Receptors
Matrix Metalloproteinases
Metabolism
Dendritic Cells
Vascular Endothelial Growth Factor A
Interleukin-6
Peptide Hydrolases
Up-Regulation
Cells

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pre-B cell colony enhancing factor (PBEF), a cytokine with multiple physiological functions. / Sun, Zhongjie; Lei, Han; Zhang, Zhonge.

In: Cytokine and Growth Factor Reviews, Vol. 24, No. 5, 01.10.2013, p. 433-442.

Research output: Contribution to journalReview article

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