Precision and accuracy of tearlab osmometer in measuring osmolarity of salt solutions

Dan Yoon, Neha Gadaria-Rathod, Cheongeun Oh, Penny Asbell

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to examine the inherent precision and accuracy of TearLab Osmolarity System using salt solutions, including solutions of very high osmolarity (>360mOsm/L). Materials and methods: Ten salt solutions with osmolarity between 286mOsm/L and 394mOsm/L (increments of 12mOsm/L) plus an additional solution of 400mOsm/L were tested twice on both the TearLab osmometer and a freezing point depression osmometer. For precision, we compared the two repeated osmolarity measurements of 11 solutions obtained from TearLab. For accuracy, we compared the averaged osmolarity measurements obtained from TearLab to those from the freezing point depression osmometer. For both precision and accuracy, Bland-Altman test of agreement was used. Results: For precision, the upper 95% limit of agreement was 4.7mOsm/L, and the lower 95% limit of agreement was-7.1mOsm/L. The repeatability coefficient was 5.9mOsm/L. For accuracy, the upper 95% limit of agreement was 4.8mOsm/L and the lower 95% limit of agreement was-5.3mOsm/L. Conclusions: The present study is the first study to demonstrate that the TearLab in situ osmometer can precisely and accurately measure osmolarity of salt solutions, including those with very high osmolarity. Future studies to evaluate the precision and the accuracy of the machine in measuring complex fluids, such as tears, need to be done, and the clinical significance of measuring tear osmolarity in patients needs to be further determined.

Original languageEnglish (US)
Pages (from-to)1247-1250
Number of pages4
JournalCurrent Eye Research
Volume39
Issue number12
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

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Osmolar Concentration
Salts
Tears
Freezing

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Precision and accuracy of tearlab osmometer in measuring osmolarity of salt solutions. / Yoon, Dan; Gadaria-Rathod, Neha; Oh, Cheongeun; Asbell, Penny.

In: Current Eye Research, Vol. 39, No. 12, 01.12.2014, p. 1247-1250.

Research output: Contribution to journalArticle

Yoon, Dan ; Gadaria-Rathod, Neha ; Oh, Cheongeun ; Asbell, Penny. / Precision and accuracy of tearlab osmometer in measuring osmolarity of salt solutions. In: Current Eye Research. 2014 ; Vol. 39, No. 12. pp. 1247-1250.
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