Prediabetes and Cardiovascular Disease

Pathophysiology and Interventions for Prevention and Risk Reduction

Ben Brannick, Samuel Dagogo-Jack

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Prediabetes is a state characterized by impaired fasting glucose or impaired glucose tolerance. This review discusses the pathophysiology and macrovascular complications of prediabetes. The pathophysiologic defects underlying prediabetes include insulin resistance, alpha- and beta-cell dysfunction, increased lipolysis, inflammation, and suboptimal incretin effect. Recent studies have revealed that the long-term complications of diabetes manifest in some people with prediabetes; these complications include microvascular and macrovascular disorders. Finally, we present an overview of randomized control trials aimed at preventing progression from prediabetes to type 2 diabetes and discuss their implications for macrovascular risk reduction.

Original languageEnglish (US)
Pages (from-to)33-50
Number of pages18
JournalEndocrinology and Metabolism Clinics of North America
Volume47
Issue number1
DOIs
StatePublished - Mar 1 2018

Fingerprint

Prediabetic State
Risk Reduction Behavior
Cardiovascular Diseases
Incretins
Glucose Intolerance
Lipolysis
Diabetes Complications
Type 2 Diabetes Mellitus
Insulin Resistance
Fasting
Inflammation
Glucose

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

@article{9b6a3cbbf82b458bb8726128f7f4e3f3,
title = "Prediabetes and Cardiovascular Disease: Pathophysiology and Interventions for Prevention and Risk Reduction",
abstract = "Prediabetes is a state characterized by impaired fasting glucose or impaired glucose tolerance. This review discusses the pathophysiology and macrovascular complications of prediabetes. The pathophysiologic defects underlying prediabetes include insulin resistance, alpha- and beta-cell dysfunction, increased lipolysis, inflammation, and suboptimal incretin effect. Recent studies have revealed that the long-term complications of diabetes manifest in some people with prediabetes; these complications include microvascular and macrovascular disorders. Finally, we present an overview of randomized control trials aimed at preventing progression from prediabetes to type 2 diabetes and discuss their implications for macrovascular risk reduction.",
author = "Ben Brannick and Samuel Dagogo-Jack",
year = "2018",
month = "3",
day = "1",
doi = "10.1016/j.ecl.2017.10.001",
language = "English (US)",
volume = "47",
pages = "33--50",
journal = "Endocrinology and Metabolism Clinics of North America",
issn = "0889-8529",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Prediabetes and Cardiovascular Disease

T2 - Pathophysiology and Interventions for Prevention and Risk Reduction

AU - Brannick, Ben

AU - Dagogo-Jack, Samuel

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Prediabetes is a state characterized by impaired fasting glucose or impaired glucose tolerance. This review discusses the pathophysiology and macrovascular complications of prediabetes. The pathophysiologic defects underlying prediabetes include insulin resistance, alpha- and beta-cell dysfunction, increased lipolysis, inflammation, and suboptimal incretin effect. Recent studies have revealed that the long-term complications of diabetes manifest in some people with prediabetes; these complications include microvascular and macrovascular disorders. Finally, we present an overview of randomized control trials aimed at preventing progression from prediabetes to type 2 diabetes and discuss their implications for macrovascular risk reduction.

AB - Prediabetes is a state characterized by impaired fasting glucose or impaired glucose tolerance. This review discusses the pathophysiology and macrovascular complications of prediabetes. The pathophysiologic defects underlying prediabetes include insulin resistance, alpha- and beta-cell dysfunction, increased lipolysis, inflammation, and suboptimal incretin effect. Recent studies have revealed that the long-term complications of diabetes manifest in some people with prediabetes; these complications include microvascular and macrovascular disorders. Finally, we present an overview of randomized control trials aimed at preventing progression from prediabetes to type 2 diabetes and discuss their implications for macrovascular risk reduction.

UR - http://www.scopus.com/inward/record.url?scp=85044634645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044634645&partnerID=8YFLogxK

U2 - 10.1016/j.ecl.2017.10.001

DO - 10.1016/j.ecl.2017.10.001

M3 - Review article

VL - 47

SP - 33

EP - 50

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

SN - 0889-8529

IS - 1

ER -