Predicting fetal lung maturity using the fetal pulmonary artery Doppler wave acceleration/ejection time ratio

Mauro Schenone, Jacques Samson, Laura Jenkins, Anju Suhag, Giancarlo Mari

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: To determine whether the acceleration/ejection time ratio of the fetal main pulmonary artery Doppler waveform (PATET) can accurately predict the results of fetal lung maturity testing in amniotic fluid.

Methods: We prospectively studied pregnant women attending our ultrasound unit for clinically indicated fetal lung maturity testing. An ultrasound examination that included measurement of the PATET was performed before the results of the amniocentesis were reported. The results of the PATET and the surfactant/ albumin ratio were compared, and a receiver operating characteristic curve was used to determine the PATET cutoff with the optimal sensitivity and specificity for predicting surfactant/ albumin ratio results. p < 0.05 was considered statistically significant.

Results: Forty-three patients were included in this study. The receiver operating characteristic curve demonstrated that a PATET cutoff of 0.3149 provided a specificity of 93% (95% CI 77-98%), a sensitivity of 73% (95% CI 48-89%), a negative predictive value of 87% (95% CI 70- 95%), and a positive predictive value of 85% (95% CI 58-96%) for predicting immature surfactant/albumin ratio results.

Conclusion: The PATET may provide a noninvasive means of determining fetal lung maturity with acceptable levels of sensitivity, specificity, and predictive values.

Original languageEnglish (US)
Pages (from-to)208-214
Number of pages7
JournalFetal Diagnosis and Therapy
Volume36
Issue number3
DOIs
StatePublished - Nov 7 2014

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Surface-Active Agents
Pulmonary Artery
Albumins
ROC Curve
Lung
Sensitivity and Specificity
Amniocentesis
Amniotic Fluid
Pregnant Women

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Predicting fetal lung maturity using the fetal pulmonary artery Doppler wave acceleration/ejection time ratio. / Schenone, Mauro; Samson, Jacques; Jenkins, Laura; Suhag, Anju; Mari, Giancarlo.

In: Fetal Diagnosis and Therapy, Vol. 36, No. 3, 07.11.2014, p. 208-214.

Research output: Contribution to journalArticle

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