Predictors of pre-eclampsia in women at high risk

S. Caritis, B. Sibai, J. Hauth, M. Lindheimer, P. Vandorsten, M. Klebanoff, E. Thom, M. Landon, R. Paul, M. Miodovnik, P. Meis, G. Thurnau, M. Dombrowski, D. McNellis, J. Roberts, J. Harger, T. Kamon, B. M. Mercer, Risa Ramsey, B. Sibai & 34 others Y. A. Rabello, D. McCart, E. Mueller, W. W. Andrews, R. Copper, G. Norman, M. Dombrowski, A. Millinder, J. T. Christmas, S. McCoy, S. Elder, N. Elder, B. Carter, V. Schneider, G. Thurneau, A. Meier, V. Minton, M. Swain, A. H. Moawad, P. Jones, J. D. Lams, S. Meadows, S. Brenner, B. A. Collins, R. B. Newman, S. G. Carter, R. Romero, V. Sabo, R. P. Bain, C. MacPherson, D. Johnson, M. L. Fischer, C. Catz, S. J. Yaffe

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: We assessed several variables as predictors for pre-eclampsia risk in a group of women at high risk. STUDY DESIGN: We studied 2503 women with either diabetes mellitus, chronic hypertension, multifetal gestation, or pre-eclampsia in a previous pregnancy who participated in a multicenter study comparing aspirin and placebo in preventing pre-eclampsia. We evaluated multiple variables for predicting pre-eclampsia risk with use of univariate and multivariable analysis. RESULTS: Parity and mean arterial pressure at randomization were most predictive of pre-eclampsia risk. The risk was 8% with a mean arterial pressure at enrollment of <75 mm Hg versus 27% with a mean arterial pressure >85 mm Hg (relative risk and 95% confidence interval 3.3 [2.4 to 4.4]). The risk of pre-eclampsia was 26% in nulliparous patients versus 17% in parous subjects (relative risk and 95% confidence interval 1.5 [1.3-1.8]). CONCLUSIONS: The finding that second-trimester mean arterial pressure affects pre-eclampsia risk suggests that the pathophysiologic process of preeclampsia is initiated before that time.

Original languageEnglish (US)
Pages (from-to)946-951
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume179
Issue number4
DOIs
StatePublished - Jan 1 1998

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Pre-Eclampsia
Arterial Pressure
Confidence Intervals
Pregnancy
Second Pregnancy Trimester
Random Allocation
Parity
Aspirin
Multicenter Studies
Diabetes Mellitus
Placebos
Hypertension

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Caritis, S., Sibai, B., Hauth, J., Lindheimer, M., Vandorsten, P., Klebanoff, M., ... Yaffe, S. J. (1998). Predictors of pre-eclampsia in women at high risk. American Journal of Obstetrics and Gynecology, 179(4), 946-951. https://doi.org/10.1016/S0002-9378(98)70194-2

Predictors of pre-eclampsia in women at high risk. / Caritis, S.; Sibai, B.; Hauth, J.; Lindheimer, M.; Vandorsten, P.; Klebanoff, M.; Thom, E.; Landon, M.; Paul, R.; Miodovnik, M.; Meis, P.; Thurnau, G.; Dombrowski, M.; McNellis, D.; Roberts, J.; Harger, J.; Kamon, T.; Mercer, B. M.; Ramsey, Risa; Sibai, B.; Rabello, Y. A.; McCart, D.; Mueller, E.; Andrews, W. W.; Copper, R.; Norman, G.; Dombrowski, M.; Millinder, A.; Christmas, J. T.; McCoy, S.; Elder, S.; Elder, N.; Carter, B.; Schneider, V.; Thurneau, G.; Meier, A.; Minton, V.; Swain, M.; Moawad, A. H.; Jones, P.; Lams, J. D.; Meadows, S.; Brenner, S.; Collins, B. A.; Newman, R. B.; Carter, S. G.; Romero, R.; Sabo, V.; Bain, R. P.; MacPherson, C.; Johnson, D.; Fischer, M. L.; Catz, C.; Yaffe, S. J.

In: American Journal of Obstetrics and Gynecology, Vol. 179, No. 4, 01.01.1998, p. 946-951.

Research output: Contribution to journalArticle

Caritis, S, Sibai, B, Hauth, J, Lindheimer, M, Vandorsten, P, Klebanoff, M, Thom, E, Landon, M, Paul, R, Miodovnik, M, Meis, P, Thurnau, G, Dombrowski, M, McNellis, D, Roberts, J, Harger, J, Kamon, T, Mercer, BM, Ramsey, R, Sibai, B, Rabello, YA, McCart, D, Mueller, E, Andrews, WW, Copper, R, Norman, G, Dombrowski, M, Millinder, A, Christmas, JT, McCoy, S, Elder, S, Elder, N, Carter, B, Schneider, V, Thurneau, G, Meier, A, Minton, V, Swain, M, Moawad, AH, Jones, P, Lams, JD, Meadows, S, Brenner, S, Collins, BA, Newman, RB, Carter, SG, Romero, R, Sabo, V, Bain, RP, MacPherson, C, Johnson, D, Fischer, ML, Catz, C & Yaffe, SJ 1998, 'Predictors of pre-eclampsia in women at high risk', American Journal of Obstetrics and Gynecology, vol. 179, no. 4, pp. 946-951. https://doi.org/10.1016/S0002-9378(98)70194-2
Caritis S, Sibai B, Hauth J, Lindheimer M, Vandorsten P, Klebanoff M et al. Predictors of pre-eclampsia in women at high risk. American Journal of Obstetrics and Gynecology. 1998 Jan 1;179(4):946-951. https://doi.org/10.1016/S0002-9378(98)70194-2
Caritis, S. ; Sibai, B. ; Hauth, J. ; Lindheimer, M. ; Vandorsten, P. ; Klebanoff, M. ; Thom, E. ; Landon, M. ; Paul, R. ; Miodovnik, M. ; Meis, P. ; Thurnau, G. ; Dombrowski, M. ; McNellis, D. ; Roberts, J. ; Harger, J. ; Kamon, T. ; Mercer, B. M. ; Ramsey, Risa ; Sibai, B. ; Rabello, Y. A. ; McCart, D. ; Mueller, E. ; Andrews, W. W. ; Copper, R. ; Norman, G. ; Dombrowski, M. ; Millinder, A. ; Christmas, J. T. ; McCoy, S. ; Elder, S. ; Elder, N. ; Carter, B. ; Schneider, V. ; Thurneau, G. ; Meier, A. ; Minton, V. ; Swain, M. ; Moawad, A. H. ; Jones, P. ; Lams, J. D. ; Meadows, S. ; Brenner, S. ; Collins, B. A. ; Newman, R. B. ; Carter, S. G. ; Romero, R. ; Sabo, V. ; Bain, R. P. ; MacPherson, C. ; Johnson, D. ; Fischer, M. L. ; Catz, C. ; Yaffe, S. J. / Predictors of pre-eclampsia in women at high risk. In: American Journal of Obstetrics and Gynecology. 1998 ; Vol. 179, No. 4. pp. 946-951.
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title = "Predictors of pre-eclampsia in women at high risk",
abstract = "OBJECTIVE: We assessed several variables as predictors for pre-eclampsia risk in a group of women at high risk. STUDY DESIGN: We studied 2503 women with either diabetes mellitus, chronic hypertension, multifetal gestation, or pre-eclampsia in a previous pregnancy who participated in a multicenter study comparing aspirin and placebo in preventing pre-eclampsia. We evaluated multiple variables for predicting pre-eclampsia risk with use of univariate and multivariable analysis. RESULTS: Parity and mean arterial pressure at randomization were most predictive of pre-eclampsia risk. The risk was 8{\%} with a mean arterial pressure at enrollment of <75 mm Hg versus 27{\%} with a mean arterial pressure >85 mm Hg (relative risk and 95{\%} confidence interval 3.3 [2.4 to 4.4]). The risk of pre-eclampsia was 26{\%} in nulliparous patients versus 17{\%} in parous subjects (relative risk and 95{\%} confidence interval 1.5 [1.3-1.8]). CONCLUSIONS: The finding that second-trimester mean arterial pressure affects pre-eclampsia risk suggests that the pathophysiologic process of preeclampsia is initiated before that time.",
author = "S. Caritis and B. Sibai and J. Hauth and M. Lindheimer and P. Vandorsten and M. Klebanoff and E. Thom and M. Landon and R. Paul and M. Miodovnik and P. Meis and G. Thurnau and M. Dombrowski and D. McNellis and J. Roberts and J. Harger and T. Kamon and Mercer, {B. M.} and Risa Ramsey and B. Sibai and Rabello, {Y. A.} and D. McCart and E. Mueller and Andrews, {W. W.} and R. Copper and G. Norman and M. Dombrowski and A. Millinder and Christmas, {J. T.} and S. McCoy and S. Elder and N. Elder and B. Carter and V. Schneider and G. Thurneau and A. Meier and V. Minton and M. Swain and Moawad, {A. H.} and P. Jones and Lams, {J. D.} and S. Meadows and S. Brenner and Collins, {B. A.} and Newman, {R. B.} and Carter, {S. G.} and R. Romero and V. Sabo and Bain, {R. P.} and C. MacPherson and D. Johnson and Fischer, {M. L.} and C. Catz and Yaffe, {S. J.}",
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T1 - Predictors of pre-eclampsia in women at high risk

AU - Caritis, S.

AU - Sibai, B.

AU - Hauth, J.

AU - Lindheimer, M.

AU - Vandorsten, P.

AU - Klebanoff, M.

AU - Thom, E.

AU - Landon, M.

AU - Paul, R.

AU - Miodovnik, M.

AU - Meis, P.

AU - Thurnau, G.

AU - Dombrowski, M.

AU - McNellis, D.

AU - Roberts, J.

AU - Harger, J.

AU - Kamon, T.

AU - Mercer, B. M.

AU - Ramsey, Risa

AU - Sibai, B.

AU - Rabello, Y. A.

AU - McCart, D.

AU - Mueller, E.

AU - Andrews, W. W.

AU - Copper, R.

AU - Norman, G.

AU - Dombrowski, M.

AU - Millinder, A.

AU - Christmas, J. T.

AU - McCoy, S.

AU - Elder, S.

AU - Elder, N.

AU - Carter, B.

AU - Schneider, V.

AU - Thurneau, G.

AU - Meier, A.

AU - Minton, V.

AU - Swain, M.

AU - Moawad, A. H.

AU - Jones, P.

AU - Lams, J. D.

AU - Meadows, S.

AU - Brenner, S.

AU - Collins, B. A.

AU - Newman, R. B.

AU - Carter, S. G.

AU - Romero, R.

AU - Sabo, V.

AU - Bain, R. P.

AU - MacPherson, C.

AU - Johnson, D.

AU - Fischer, M. L.

AU - Catz, C.

AU - Yaffe, S. J.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - OBJECTIVE: We assessed several variables as predictors for pre-eclampsia risk in a group of women at high risk. STUDY DESIGN: We studied 2503 women with either diabetes mellitus, chronic hypertension, multifetal gestation, or pre-eclampsia in a previous pregnancy who participated in a multicenter study comparing aspirin and placebo in preventing pre-eclampsia. We evaluated multiple variables for predicting pre-eclampsia risk with use of univariate and multivariable analysis. RESULTS: Parity and mean arterial pressure at randomization were most predictive of pre-eclampsia risk. The risk was 8% with a mean arterial pressure at enrollment of <75 mm Hg versus 27% with a mean arterial pressure >85 mm Hg (relative risk and 95% confidence interval 3.3 [2.4 to 4.4]). The risk of pre-eclampsia was 26% in nulliparous patients versus 17% in parous subjects (relative risk and 95% confidence interval 1.5 [1.3-1.8]). CONCLUSIONS: The finding that second-trimester mean arterial pressure affects pre-eclampsia risk suggests that the pathophysiologic process of preeclampsia is initiated before that time.

AB - OBJECTIVE: We assessed several variables as predictors for pre-eclampsia risk in a group of women at high risk. STUDY DESIGN: We studied 2503 women with either diabetes mellitus, chronic hypertension, multifetal gestation, or pre-eclampsia in a previous pregnancy who participated in a multicenter study comparing aspirin and placebo in preventing pre-eclampsia. We evaluated multiple variables for predicting pre-eclampsia risk with use of univariate and multivariable analysis. RESULTS: Parity and mean arterial pressure at randomization were most predictive of pre-eclampsia risk. The risk was 8% with a mean arterial pressure at enrollment of <75 mm Hg versus 27% with a mean arterial pressure >85 mm Hg (relative risk and 95% confidence interval 3.3 [2.4 to 4.4]). The risk of pre-eclampsia was 26% in nulliparous patients versus 17% in parous subjects (relative risk and 95% confidence interval 1.5 [1.3-1.8]). CONCLUSIONS: The finding that second-trimester mean arterial pressure affects pre-eclampsia risk suggests that the pathophysiologic process of preeclampsia is initiated before that time.

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