Preferential loss of striato‐external pallidal projection neurons in presymptomatic Huntington's disease

Roger L. Albin, Anton Reiner, Keith D. Anderson, Leon S. Dure, Barbara Handelin, Rosemary Balfour, William O. Whetsell, John B. Penney, Anne B. Young

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

We have reported previously that striatal projection neurons are differentially affected in the course of Huntington's disease, and in a prior patient report we noted that differential loss of striatal projection neurons occurs also in patients with presymptomatic Huntington's disease. Striatal neurons projecting to the external segment of the globus pallidus or the substantia nigra show evident loss, whereas those projecting to the internal segment of the globus pallidus appear relatively spared at presymptomatic and early stages of symptomatic Huntington's disease. We now report similar findings in a second apparently presymptomatic Huntington's disease allele carrier.

Original languageEnglish (US)
Pages (from-to)425-430
Number of pages6
JournalAnnals of Neurology
Volume31
Issue number4
DOIs
StatePublished - Jan 1 1992

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Asymptomatic Diseases
Huntington Disease
Corpus Striatum
Neurons
Globus Pallidus
Substantia Nigra
Alleles

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Albin, R. L., Reiner, A., Anderson, K. D., Dure, L. S., Handelin, B., Balfour, R., ... Young, A. B. (1992). Preferential loss of striato‐external pallidal projection neurons in presymptomatic Huntington's disease. Annals of Neurology, 31(4), 425-430. https://doi.org/10.1002/ana.410310412

Preferential loss of striato‐external pallidal projection neurons in presymptomatic Huntington's disease. / Albin, Roger L.; Reiner, Anton; Anderson, Keith D.; Dure, Leon S.; Handelin, Barbara; Balfour, Rosemary; Whetsell, William O.; Penney, John B.; Young, Anne B.

In: Annals of Neurology, Vol. 31, No. 4, 01.01.1992, p. 425-430.

Research output: Contribution to journalArticle

Albin, RL, Reiner, A, Anderson, KD, Dure, LS, Handelin, B, Balfour, R, Whetsell, WO, Penney, JB & Young, AB 1992, 'Preferential loss of striato‐external pallidal projection neurons in presymptomatic Huntington's disease', Annals of Neurology, vol. 31, no. 4, pp. 425-430. https://doi.org/10.1002/ana.410310412
Albin, Roger L. ; Reiner, Anton ; Anderson, Keith D. ; Dure, Leon S. ; Handelin, Barbara ; Balfour, Rosemary ; Whetsell, William O. ; Penney, John B. ; Young, Anne B. / Preferential loss of striato‐external pallidal projection neurons in presymptomatic Huntington's disease. In: Annals of Neurology. 1992 ; Vol. 31, No. 4. pp. 425-430.
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