Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity

N. Schlabritz-Loutsevitch, K. Apostolakis-Kyrus, R. Krutilina, G. Hubbard, Mehmet Kocak, Z. Janjetovic, Shyam Sathanandam, A. T. Slominski, Giancarlo Mari, E. Dick

Research output: Contribution to journalArticle

Abstract

Background: Obesity in pregnancy (MO) is a risk factor for maternal and/or fetal cardiovascular system disorders. This study evaluated maternal CVS expression of microRNA-29 family and its target molecules in MO to test the hypotheses: CVS miR-29 concentrations are increased in pregnancy and decreased in MO. Methods: Non-pregnant (n=4), pregnant obese (POb, n=4), and pregnant non-obese (PnOb, n=4) baboons (Papio spp.) were studied. Maternal left ventricle (LV), left atrium (LA), and aortic arch (AA) were collected at the end of gestation. Expression of MiR-29 and elastin (ELN) mRNA were quantified. Results: LA miR-29 (a, c) expression was highest in PnOb. In the LV, miR-29b expression trended lower (P=.059) for PnOb animals. ELN mRNA expression correlated positively with miR-29b expression in AA (r=.76, P=.03). Conclusion: Maternal obesity diminishes miR-29 adaptation to pregnancy. Pharmacologic, tissue-specific targeting of miRNA-29 may represent a strategy for prevention and treatment of MO complications.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalJournal of Medical Primatology
Volume45
Issue number6
DOIs
StatePublished - Dec 1 2016

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obesity
Obesity
Mothers
pregnancy
elastin
Pregnancy
Elastin
Papio
Heart Atria
MicroRNAs
Thoracic Aorta
microRNA
Heart Ventricles
Messenger RNA
cardiovascular system
Cardiovascular System
risk factors
animals
testing
methodology

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Schlabritz-Loutsevitch, N., Apostolakis-Kyrus, K., Krutilina, R., Hubbard, G., Kocak, M., Janjetovic, Z., ... Dick, E. (2016). Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity. Journal of Medical Primatology, 45(6), 297-303. https://doi.org/10.1111/jmp.12236

Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity. / Schlabritz-Loutsevitch, N.; Apostolakis-Kyrus, K.; Krutilina, R.; Hubbard, G.; Kocak, Mehmet; Janjetovic, Z.; Sathanandam, Shyam; Slominski, A. T.; Mari, Giancarlo; Dick, E.

In: Journal of Medical Primatology, Vol. 45, No. 6, 01.12.2016, p. 297-303.

Research output: Contribution to journalArticle

Schlabritz-Loutsevitch, N, Apostolakis-Kyrus, K, Krutilina, R, Hubbard, G, Kocak, M, Janjetovic, Z, Sathanandam, S, Slominski, AT, Mari, G & Dick, E 2016, 'Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity', Journal of Medical Primatology, vol. 45, no. 6, pp. 297-303. https://doi.org/10.1111/jmp.12236
Schlabritz-Loutsevitch N, Apostolakis-Kyrus K, Krutilina R, Hubbard G, Kocak M, Janjetovic Z et al. Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity. Journal of Medical Primatology. 2016 Dec 1;45(6):297-303. https://doi.org/10.1111/jmp.12236
Schlabritz-Loutsevitch, N. ; Apostolakis-Kyrus, K. ; Krutilina, R. ; Hubbard, G. ; Kocak, Mehmet ; Janjetovic, Z. ; Sathanandam, Shyam ; Slominski, A. T. ; Mari, Giancarlo ; Dick, E. / Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity. In: Journal of Medical Primatology. 2016 ; Vol. 45, No. 6. pp. 297-303.
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abstract = "Background: Obesity in pregnancy (MO) is a risk factor for maternal and/or fetal cardiovascular system disorders. This study evaluated maternal CVS expression of microRNA-29 family and its target molecules in MO to test the hypotheses: CVS miR-29 concentrations are increased in pregnancy and decreased in MO. Methods: Non-pregnant (n=4), pregnant obese (POb, n=4), and pregnant non-obese (PnOb, n=4) baboons (Papio spp.) were studied. Maternal left ventricle (LV), left atrium (LA), and aortic arch (AA) were collected at the end of gestation. Expression of MiR-29 and elastin (ELN) mRNA were quantified. Results: LA miR-29 (a, c) expression was highest in PnOb. In the LV, miR-29b expression trended lower (P=.059) for PnOb animals. ELN mRNA expression correlated positively with miR-29b expression in AA (r=.76, P=.03). Conclusion: Maternal obesity diminishes miR-29 adaptation to pregnancy. Pharmacologic, tissue-specific targeting of miRNA-29 may represent a strategy for prevention and treatment of MO complications.",
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AU - Janjetovic, Z.

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N2 - Background: Obesity in pregnancy (MO) is a risk factor for maternal and/or fetal cardiovascular system disorders. This study evaluated maternal CVS expression of microRNA-29 family and its target molecules in MO to test the hypotheses: CVS miR-29 concentrations are increased in pregnancy and decreased in MO. Methods: Non-pregnant (n=4), pregnant obese (POb, n=4), and pregnant non-obese (PnOb, n=4) baboons (Papio spp.) were studied. Maternal left ventricle (LV), left atrium (LA), and aortic arch (AA) were collected at the end of gestation. Expression of MiR-29 and elastin (ELN) mRNA were quantified. Results: LA miR-29 (a, c) expression was highest in PnOb. In the LV, miR-29b expression trended lower (P=.059) for PnOb animals. ELN mRNA expression correlated positively with miR-29b expression in AA (r=.76, P=.03). Conclusion: Maternal obesity diminishes miR-29 adaptation to pregnancy. Pharmacologic, tissue-specific targeting of miRNA-29 may represent a strategy for prevention and treatment of MO complications.

AB - Background: Obesity in pregnancy (MO) is a risk factor for maternal and/or fetal cardiovascular system disorders. This study evaluated maternal CVS expression of microRNA-29 family and its target molecules in MO to test the hypotheses: CVS miR-29 concentrations are increased in pregnancy and decreased in MO. Methods: Non-pregnant (n=4), pregnant obese (POb, n=4), and pregnant non-obese (PnOb, n=4) baboons (Papio spp.) were studied. Maternal left ventricle (LV), left atrium (LA), and aortic arch (AA) were collected at the end of gestation. Expression of MiR-29 and elastin (ELN) mRNA were quantified. Results: LA miR-29 (a, c) expression was highest in PnOb. In the LV, miR-29b expression trended lower (P=.059) for PnOb animals. ELN mRNA expression correlated positively with miR-29b expression in AA (r=.76, P=.03). Conclusion: Maternal obesity diminishes miR-29 adaptation to pregnancy. Pharmacologic, tissue-specific targeting of miRNA-29 may represent a strategy for prevention and treatment of MO complications.

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