Preliminary Findings

25(OH)D Levels and PTH Are Indicators of Rapid Bone Accrual in Pubertal Children

Frances Tylavsky, Kathryn M. Ryder, Rongling Li, Vicki Park, Catherine Womack, John Norwood, Laura D. Carbone, Sulin Cheng

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: The objective of this study was to evaluate the role of serum levels of 25(OH)D and PTH on the accumulation of whole body bone mass in a cohort of children. Methods: This was a longitudinal study (1.98 ± 0.07 y) of sixty-nine children (89% Caucasian, 44% male) enrolled in a calcium supplementation trial. Bone area, bone mineral content (BMC) and density (BMD) of the whole body and radius were assessed using a QDR 2000 (Hologic, Inc) dual energy x-ray absorptiometer. Serum PTH and 25(OH)D were measured using radioimmunoassays. Results: Vitamin D stores were inversely related gain in bone area (p < 0.002), BMC (p < 0.002) BMD (p < 0.027), as well as to PTH levels (p < 0.0001). Compared to those with adequate vitamin D stores (>34 ng/ml), those who had consistently low vitamin D stores (18 ng/ml) had a 8% larger gain in bone area (p < 0.05); 11% in BMC (p < 0.05) and no differences in gain in BMD; after adjusting for baseline bone measurements, race, gender, season measured, Tanner stage, and calcium intake. Conclusions: High normal PTH with low-normal 25(OH)D stores and moderate to high calcium intake may be beneficial to accruing larger bone size and BMC during puberty.

Original languageEnglish (US)
Pages (from-to)462-470
Number of pages9
JournalJournal of the American College of Nutrition
Volume26
Issue number5
DOIs
StatePublished - Oct 1 2007

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Bone and Bones
Bone Density
Calcium
Vitamin D
Puberty
Serum
Radioimmunoassay
Longitudinal Studies
X-Rays

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Preliminary Findings : 25(OH)D Levels and PTH Are Indicators of Rapid Bone Accrual in Pubertal Children. / Tylavsky, Frances; Ryder, Kathryn M.; Li, Rongling; Park, Vicki; Womack, Catherine; Norwood, John; Carbone, Laura D.; Cheng, Sulin.

In: Journal of the American College of Nutrition, Vol. 26, No. 5, 01.10.2007, p. 462-470.

Research output: Contribution to journalArticle

Tylavsky, Frances ; Ryder, Kathryn M. ; Li, Rongling ; Park, Vicki ; Womack, Catherine ; Norwood, John ; Carbone, Laura D. ; Cheng, Sulin. / Preliminary Findings : 25(OH)D Levels and PTH Are Indicators of Rapid Bone Accrual in Pubertal Children. In: Journal of the American College of Nutrition. 2007 ; Vol. 26, No. 5. pp. 462-470.
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