Prenatal development of gastrointestinal function in the pig and the effects of fetal esophageal obstruction

Per T. Sangild, Mette Schmidt, Jan Elnif, Charlotte R. Björnvad, Björn R. Weström, Randal Buddington

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Maturation of the fetal gastrointestinal tract (GIT) is influenced by both luminal stimuli (e.g. swallowed fluid) and hormonal factors (e.g. endogenous cortisol release). The aims of the present study were 1) to investigate GIT growth and maturation during the last 20% of gestation in pigs (term = 114 ± 2 d), and 2) to investigate the effect of esophageal ligation, to prevent fetal swallowing, at 80% to 91% gestation. In normal fetuses, marked increases occurred during late gestation in body weight (+95%), relative intestinal weight (+79%, g kg-1 body weight), activity of some digestive enzymes (1.5- to 10-fold), and absorption of glucose and intact proteins (3- to 6-fold). Fetuses with ligated esophagi had lowered body weight (-20%), reduced intestinal weight (-43%), aminopeptidase A activity (-24%), and glucose absorption (-27%), while lactase, sucrase, and dipeptidylpeptidase IV activities were increased (+40-50%), compared with sham-operated fetuses (all p < 0.05). Other parameters of GIT function remained unchanged by esophageal obstruction (absorption of amino acids and immunoglobulin, activity of chymosin, amylase, trypsin, chymotrypsin, maltase, aminopeptidase N - all expressed per gram GIT tissue). Ligated fetuses had elevated cortisol levels, which is known to stimulate fetal GIT maturation. We conclude that the rapid development of GIT function in late gestation is diminished by esophageal obstruction, mainly due to slower GIT growth and not inhibition of normal functional development of enterocytes.

Original languageEnglish (US)
Pages (from-to)416-424
Number of pages9
JournalPediatric Research
Volume52
Issue number3
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Gastrointestinal Tract
Swine
Fetus
Pregnancy
Body Weight
Hydrocortisone
Glutamyl Aminopeptidase
Chymosin
Sucrase
CD13 Antigens
Lactase
Weights and Measures
Glucose
alpha-Glucosidases
Enterocytes
Amylases
Deglutition
Growth
Esophagus
Ligation

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Prenatal development of gastrointestinal function in the pig and the effects of fetal esophageal obstruction. / Sangild, Per T.; Schmidt, Mette; Elnif, Jan; Björnvad, Charlotte R.; Weström, Björn R.; Buddington, Randal.

In: Pediatric Research, Vol. 52, No. 3, 01.01.2002, p. 416-424.

Research output: Contribution to journalArticle

Sangild, Per T. ; Schmidt, Mette ; Elnif, Jan ; Björnvad, Charlotte R. ; Weström, Björn R. ; Buddington, Randal. / Prenatal development of gastrointestinal function in the pig and the effects of fetal esophageal obstruction. In: Pediatric Research. 2002 ; Vol. 52, No. 3. pp. 416-424.
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