Pressure-dependent attenuation in ultrasound contrast agents

Quan Chen, James Zagzebski, Thaddeus Wilson, Timothy Stiles

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Although microbubble contrast agents are believed to respond differently under different driving-pressure amplitudes, few studies have been performed to extensively study the pressure-dependence of their properties. In this paper, attenuation coefficients of two contrast agents (Optison™ and Definity™) were measured under different driving-pressure amplitudes using a narrowband incident pulse. The attenuation of both contrast agents was found to increase with increasing driving pressure. Simulations using the Rayleigh, Plesset, Noltingk, Neppiras, Poritsky (RPNNP) equation were performed to study this behavior. Simulation results show that significant harmonic generation at high driving-pressure amplitudes contributes to the higher attenuation. Other possible explanations for this behavior were also examined. Attenuation coefficients of two contrast agents were also measured using a broadband method. The results showed great inconsistency when the center frequency of the incident broadband pulse was changed, indicating that broadband techniques may not be suitable for contrast-agent attenuation measurements.

Original languageEnglish (US)
Pages (from-to)1041-1051
Number of pages11
JournalUltrasound in Medicine and Biology
Volume28
Issue number8
DOIs
StatePublished - Aug 1 2002

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Contrast Media
attenuation
Pressure
attenuation coefficients
broadband
Microbubbles
pulses
pressure dependence
narrowband
harmonic generations
simulation

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

Pressure-dependent attenuation in ultrasound contrast agents. / Chen, Quan; Zagzebski, James; Wilson, Thaddeus; Stiles, Timothy.

In: Ultrasound in Medicine and Biology, Vol. 28, No. 8, 01.08.2002, p. 1041-1051.

Research output: Contribution to journalArticle

Chen, Quan ; Zagzebski, James ; Wilson, Thaddeus ; Stiles, Timothy. / Pressure-dependent attenuation in ultrasound contrast agents. In: Ultrasound in Medicine and Biology. 2002 ; Vol. 28, No. 8. pp. 1041-1051.
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