Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs.

Per T. Sangild, Yvette M. Petersen, Mette Schmidt, Jan Elnif, Thomas K. Petersen, Randal Buddington, Gorm Greisen, Kim F. Michaelsen, Douglas G. Burrin

Research output: Contribution to journalArticle

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Abstract

Maturation of gastrointestinal (GI) function in neonates is stimulated by enteral nutrition, whereas parenteral nutrition induces GI atrophy and malfunction. We investigated whether preterm birth alters the GI responses to parenteral and enteral nutrition. Pigs were delivered either preterm (107 d gestation) or at term (115 d gestation) and fed total parenteral nutrition (TPN) or enteral sow's milk (ENT) for 6 d after birth. Immaturity of the preterm pigs was documented by reduced blood pH, oxygen saturation and neutrophil granulocyte function, impaired intestinal immunoglobulin G uptake from colostrum, and altered relative weights of visceral organs (small intestine, liver, spleen, pancreas, and adrenals). For both ages at delivery, increases occurred in pancreatic weight (30-75%) and amylase activity (0.5- to 13-fold) after birth, but much more in ENT than in TPN pigs (P < 0.05). Six days of TPN feeding was associated with reduced intestinal weight for both delivery groups (60% of values in ENT, P < 0.001), but only in term TPN pigs was the weight lower than at birth (-20%, P < 0.05). Likewise, it was only in term TPN pigs that intestinal maltase activity increased, compared with ENT, and the absorption of glucose and proline decreased. Only in preterm pigs did TPN feeding increase lactase activity (+50% compared with ENT, P < 0.05). For both delivery ages, the mRNA of lactase-phloridzin hydrolase and sodium-coupled glucose transporter 1 (SGLT-1) were increased in TPN, compared with ENT. In conclusion, the trophic effect of enteral vs. parenteral nutrition on the GI tract is also present after preterm birth, but the postnatal maturation of many GI functions is modified, compared with term birth. The effects of nutritional regimen on the maturation of the gut epithelium in neonates depend on gestational age at birth.

Original languageEnglish (US)
Pages (from-to)3786-3794
Number of pages9
JournalThe Journal of nutrition
Volume132
Issue number12
StatePublished - Jan 1 2002
Externally publishedYes

Fingerprint

premature birth
Total Parenteral Nutrition
total parenteral nutrition
Parenteral Nutrition
Premature Birth
enteral feeding
Enteral Nutrition
parenteral feeding
neonates
Swine
swine
Parturition
Small Intestine
Lactase
beta-galactosidase
Weights and Measures
Sodium-Glucose Transporter 1
pregnancy
Term Birth
Phlorhizin

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Sangild, P. T., Petersen, Y. M., Schmidt, M., Elnif, J., Petersen, T. K., Buddington, R., ... Burrin, D. G. (2002). Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs. The Journal of nutrition, 132(12), 3786-3794.

Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs. / Sangild, Per T.; Petersen, Yvette M.; Schmidt, Mette; Elnif, Jan; Petersen, Thomas K.; Buddington, Randal; Greisen, Gorm; Michaelsen, Kim F.; Burrin, Douglas G.

In: The Journal of nutrition, Vol. 132, No. 12, 01.01.2002, p. 3786-3794.

Research output: Contribution to journalArticle

Sangild, PT, Petersen, YM, Schmidt, M, Elnif, J, Petersen, TK, Buddington, R, Greisen, G, Michaelsen, KF & Burrin, DG 2002, 'Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs.', The Journal of nutrition, vol. 132, no. 12, pp. 3786-3794.
Sangild PT, Petersen YM, Schmidt M, Elnif J, Petersen TK, Buddington R et al. Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs. The Journal of nutrition. 2002 Jan 1;132(12):3786-3794.
Sangild, Per T. ; Petersen, Yvette M. ; Schmidt, Mette ; Elnif, Jan ; Petersen, Thomas K. ; Buddington, Randal ; Greisen, Gorm ; Michaelsen, Kim F. ; Burrin, Douglas G. / Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs. In: The Journal of nutrition. 2002 ; Vol. 132, No. 12. pp. 3786-3794.
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abstract = "Maturation of gastrointestinal (GI) function in neonates is stimulated by enteral nutrition, whereas parenteral nutrition induces GI atrophy and malfunction. We investigated whether preterm birth alters the GI responses to parenteral and enteral nutrition. Pigs were delivered either preterm (107 d gestation) or at term (115 d gestation) and fed total parenteral nutrition (TPN) or enteral sow's milk (ENT) for 6 d after birth. Immaturity of the preterm pigs was documented by reduced blood pH, oxygen saturation and neutrophil granulocyte function, impaired intestinal immunoglobulin G uptake from colostrum, and altered relative weights of visceral organs (small intestine, liver, spleen, pancreas, and adrenals). For both ages at delivery, increases occurred in pancreatic weight (30-75{\%}) and amylase activity (0.5- to 13-fold) after birth, but much more in ENT than in TPN pigs (P < 0.05). Six days of TPN feeding was associated with reduced intestinal weight for both delivery groups (60{\%} of values in ENT, P < 0.001), but only in term TPN pigs was the weight lower than at birth (-20{\%}, P < 0.05). Likewise, it was only in term TPN pigs that intestinal maltase activity increased, compared with ENT, and the absorption of glucose and proline decreased. Only in preterm pigs did TPN feeding increase lactase activity (+50{\%} compared with ENT, P < 0.05). For both delivery ages, the mRNA of lactase-phloridzin hydrolase and sodium-coupled glucose transporter 1 (SGLT-1) were increased in TPN, compared with ENT. In conclusion, the trophic effect of enteral vs. parenteral nutrition on the GI tract is also present after preterm birth, but the postnatal maturation of many GI functions is modified, compared with term birth. The effects of nutritional regimen on the maturation of the gut epithelium in neonates depend on gestational age at birth.",
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