Preterm Infants Can Mount Appropriate C-Reactive Protein Responses to Early Onset Sepsis

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Abstract

Objective This study aims to evaluate whether infants born at ≤ 32 weeks' gestational age (GA) can mount C-reactive protein (CRP) responses during early onset bacterial sepsis that are comparable to infants born at > 32 weeks' GA. Methods Retrospectively (2003-2012) infants with a positive bacterial culture during the first 72 hours of life were identified and grouped into two categories based on their GA: ≤ 32 weeks (group A) and > 32 weeks (group B). Results Group A included 25 and group B included 122 infants. Both groups responded similarly to sepsis with an increase in CRP (p = 0.59). Each group had a significant change in intragroup CRP levels over time (p < 0.0001). However, in both groups, the degree of this change was at the same rate over time (p = 0.74). Conclusion CRP responses to bacterial sepsis during the first 72 hours of life in infants born at ≤ 32 weeks' GA are comparable to infants born at > 32 weeks' GA.

Original languageEnglish (US)
Pages (from-to)1281-1286
Number of pages6
JournalAmerican Journal of Perinatology
Volume32
Issue number13
DOIs
StatePublished - Jun 12 2015

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Premature Infants
C-Reactive Protein
Gestational Age
Sepsis

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

@article{fc7646d0549b4d9e8e623bdeead9c878,
title = "Preterm Infants Can Mount Appropriate C-Reactive Protein Responses to Early Onset Sepsis",
abstract = "Objective This study aims to evaluate whether infants born at ≤ 32 weeks' gestational age (GA) can mount C-reactive protein (CRP) responses during early onset bacterial sepsis that are comparable to infants born at > 32 weeks' GA. Methods Retrospectively (2003-2012) infants with a positive bacterial culture during the first 72 hours of life were identified and grouped into two categories based on their GA: ≤ 32 weeks (group A) and > 32 weeks (group B). Results Group A included 25 and group B included 122 infants. Both groups responded similarly to sepsis with an increase in CRP (p = 0.59). Each group had a significant change in intragroup CRP levels over time (p < 0.0001). However, in both groups, the degree of this change was at the same rate over time (p = 0.74). Conclusion CRP responses to bacterial sepsis during the first 72 hours of life in infants born at ≤ 32 weeks' GA are comparable to infants born at > 32 weeks' GA.",
author = "Shah, {Sanket D.} and Ajay Talati and Mohamad Elabiad and Ramasubbareddy Dhanireddy and Massroor Pourcyrous",
year = "2015",
month = "6",
day = "12",
doi = "10.1055/s-0035-1555127",
language = "English (US)",
volume = "32",
pages = "1281--1286",
journal = "American Journal of Perinatology",
issn = "0735-1631",
publisher = "Thieme Medical Publishers",
number = "13",

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TY - JOUR

T1 - Preterm Infants Can Mount Appropriate C-Reactive Protein Responses to Early Onset Sepsis

AU - Shah, Sanket D.

AU - Talati, Ajay

AU - Elabiad, Mohamad

AU - Dhanireddy, Ramasubbareddy

AU - Pourcyrous, Massroor

PY - 2015/6/12

Y1 - 2015/6/12

N2 - Objective This study aims to evaluate whether infants born at ≤ 32 weeks' gestational age (GA) can mount C-reactive protein (CRP) responses during early onset bacterial sepsis that are comparable to infants born at > 32 weeks' GA. Methods Retrospectively (2003-2012) infants with a positive bacterial culture during the first 72 hours of life were identified and grouped into two categories based on their GA: ≤ 32 weeks (group A) and > 32 weeks (group B). Results Group A included 25 and group B included 122 infants. Both groups responded similarly to sepsis with an increase in CRP (p = 0.59). Each group had a significant change in intragroup CRP levels over time (p < 0.0001). However, in both groups, the degree of this change was at the same rate over time (p = 0.74). Conclusion CRP responses to bacterial sepsis during the first 72 hours of life in infants born at ≤ 32 weeks' GA are comparable to infants born at > 32 weeks' GA.

AB - Objective This study aims to evaluate whether infants born at ≤ 32 weeks' gestational age (GA) can mount C-reactive protein (CRP) responses during early onset bacterial sepsis that are comparable to infants born at > 32 weeks' GA. Methods Retrospectively (2003-2012) infants with a positive bacterial culture during the first 72 hours of life were identified and grouped into two categories based on their GA: ≤ 32 weeks (group A) and > 32 weeks (group B). Results Group A included 25 and group B included 122 infants. Both groups responded similarly to sepsis with an increase in CRP (p = 0.59). Each group had a significant change in intragroup CRP levels over time (p < 0.0001). However, in both groups, the degree of this change was at the same rate over time (p = 0.74). Conclusion CRP responses to bacterial sepsis during the first 72 hours of life in infants born at ≤ 32 weeks' GA are comparable to infants born at > 32 weeks' GA.

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U2 - 10.1055/s-0035-1555127

DO - 10.1055/s-0035-1555127

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JO - American Journal of Perinatology

JF - American Journal of Perinatology

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