Pretherapy Gallium-67 Scanning in Paediatric Patients with Hodgkin's Disease

G. M. Shah Syed, M. N. Younis, G. N. Usmani, Nadeem Zafar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To investigate the correlation between gallium-67 ( 67Ga) uptake and histological subtypes of Hodgkin's disease (HD) in paediatric patients. Subjects and Methods: Fifty-eight patients (45 males and 13 females aged 9.2 ± 4 years, range 1.5-17 years) with histologically diagnosed HD underwent pretherapy 67Ga scanning on days 2, 5, 12 or 14 days after intravenous administration of 25-50 MBq (0.7-1.4 mCi) of 67Ga citrate. The scans were evaluated both visually and quantitatively using the activity of 67Ga in the liver as a reference. Clinical outcome of 11 patients with high diffuse 67Ga skeletal uptake was compared with that of 17 patients showing normal distribution of 67Ga in the skeleton. Results: Of the 58 patients, the 67Ga scans were positive in 47 patients with 117 lesions. Visual analysis did not differentiate between the histological variants of HD. However, quantitative analysis of lesion-to-liver ratios showed significantly higher values of 67Ga uptake in the mixed cellularity type than in the nodular sclerosis type (t = -3.7, p < 0.001). Patients with high skeletal uptake had a higher relapse rate (6/11) than those with normal skeletal uptake (3/17). Conclusion: The findings show that quantitative analysis of 67Ga uptake can differentiate between the two main subtypes of HD (mixed cellularity and nodular sclerosis). Further diffuse skeletal uptake of 67Ga indicates a higher relapse rate.

Original languageEnglish (US)
Pages (from-to)74-77
Number of pages4
JournalMedical Principles and Practice
Volume13
Issue number2
DOIs
StatePublished - Feb 23 2004

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Gallium
Hodgkin Disease
Pediatrics
Sclerosis
Recurrence
Liver
Normal Distribution
Skeleton
Citric Acid
Intravenous Administration

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Pretherapy Gallium-67 Scanning in Paediatric Patients with Hodgkin's Disease. / Shah Syed, G. M.; Younis, M. N.; Usmani, G. N.; Zafar, Nadeem.

In: Medical Principles and Practice, Vol. 13, No. 2, 23.02.2004, p. 74-77.

Research output: Contribution to journalArticle

Shah Syed, G. M. ; Younis, M. N. ; Usmani, G. N. ; Zafar, Nadeem. / Pretherapy Gallium-67 Scanning in Paediatric Patients with Hodgkin's Disease. In: Medical Principles and Practice. 2004 ; Vol. 13, No. 2. pp. 74-77.
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