Pretransplant transfusions in cardiac allograft recipients

Marc R. Katz, Glenn R. Barnhart, Mitchell Goldman, Sheelah Rider, Andrea Hastillo, Szabolcs Szentpetery, Timothy C. Wolfgang, Michael L. Hess, Thalachallour Mohanakumar, Richard R. Lower

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The role of pretransplant transfusion in cardiac allograft recipients was determined retrospectively in 68 patients. Three groups were studied: group 1 (n=29) received no pretransplant transfusion, group 2 (n=15) received transfusion over one year prior to transplantation, and Group 3 (n=24) received 5 or 10 50—100 ml units of random donor red blood cells or buffy coat 2-4 weeks prior to transplantation. Data were analyzed for survival, number of rejection episodes, and number of infections. Immunosuppression included azathioprine, prednisone, and antithymocyte globulin. Survival in transfused patients (groups 2 and 3) was 68% and 51% at 1 and 5 years, respectively, while in the nontrans-fused population (group 1) it was 35% and 16%. The incidence of rejection episodes per year of survival was similar in the three groups (group 1: 1.3, group 2: 1.1, group 3: 1.3; P>0.05). The number of infections per year of survival were greater in the transfused patients but this did not achieve statistical significance (group 1: 1.0, group 2: 1.2, group 3: 1.7; P>0.05). Thus, we conclude that cardiac transplant recipients who have received blood transfusions prior to transplantation may have enhanced survival over patients who have not received preoperative transfusions.

Original languageEnglish (US)
Pages (from-to)499-501
Number of pages3
JournalTransplantation
Volume43
Issue number4
StatePublished - Jan 1 1987
Externally publishedYes

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Allografts
Survival
Transplantation
Antilymphocyte Serum
Azathioprine
Prednisone
Infection
Population Groups
Blood Transfusion
Immunosuppression
Erythrocytes
Tissue Donors
Incidence

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Katz, M. R., Barnhart, G. R., Goldman, M., Rider, S., Hastillo, A., Szentpetery, S., ... Lower, R. R. (1987). Pretransplant transfusions in cardiac allograft recipients. Transplantation, 43(4), 499-501.

Pretransplant transfusions in cardiac allograft recipients. / Katz, Marc R.; Barnhart, Glenn R.; Goldman, Mitchell; Rider, Sheelah; Hastillo, Andrea; Szentpetery, Szabolcs; Wolfgang, Timothy C.; Hess, Michael L.; Mohanakumar, Thalachallour; Lower, Richard R.

In: Transplantation, Vol. 43, No. 4, 01.01.1987, p. 499-501.

Research output: Contribution to journalArticle

Katz, MR, Barnhart, GR, Goldman, M, Rider, S, Hastillo, A, Szentpetery, S, Wolfgang, TC, Hess, ML, Mohanakumar, T & Lower, RR 1987, 'Pretransplant transfusions in cardiac allograft recipients', Transplantation, vol. 43, no. 4, pp. 499-501.
Katz MR, Barnhart GR, Goldman M, Rider S, Hastillo A, Szentpetery S et al. Pretransplant transfusions in cardiac allograft recipients. Transplantation. 1987 Jan 1;43(4):499-501.
Katz, Marc R. ; Barnhart, Glenn R. ; Goldman, Mitchell ; Rider, Sheelah ; Hastillo, Andrea ; Szentpetery, Szabolcs ; Wolfgang, Timothy C. ; Hess, Michael L. ; Mohanakumar, Thalachallour ; Lower, Richard R. / Pretransplant transfusions in cardiac allograft recipients. In: Transplantation. 1987 ; Vol. 43, No. 4. pp. 499-501.
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