Prevention of immune graft rejection after corneal transplantation

James Fleming, Francis R. Reid, Thomas O. Wood

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effectiveness of fluorometholone was compared to dexamethasone phosphate and prednisolone acetate in preventing the immune corneal graft reaction in rabbits. Clear corneal grafts were obtained. Rejection was induced after skin from the corneal donor animal was grafted subcutaneously in the host animal and the animals were randomized into four treatment groups. Rejection occurred in eight of nine rabbits in the control group; one of eight in the dexamethasone phosphate group; one of eight in the fluorometholone group; and one of ten in the prednisolone acetate group. Histologic examination confirmed the above findings. In this animal study fluorometholone prevented immune graft rejection in a percentage similar to that of prednisolone acetate and dexamethasone phosphate.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume88
Issue number1
DOIs
StatePublished - Jan 1 1979

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dexamethasone 21-phosphate
Fluorometholone
Corneal Transplantation
Graft Rejection
Rabbits
Transplants
Control Groups
Skin
prednisolone acetate

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Prevention of immune graft rejection after corneal transplantation. / Fleming, James; Reid, Francis R.; Wood, Thomas O.

In: American Journal of Ophthalmology, Vol. 88, No. 1, 01.01.1979, p. 97-101.

Research output: Contribution to journalArticle

Fleming, James ; Reid, Francis R. ; Wood, Thomas O. / Prevention of immune graft rejection after corneal transplantation. In: American Journal of Ophthalmology. 1979 ; Vol. 88, No. 1. pp. 97-101.
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