Primary malignant melanoma of the urethra a clinicopathologic analysis of 15 cases

Esther Oliva, Timothy R. Quinn, Mahul Amin, John N. Eble, Jonathan I. Epstein, John R. Srigley, Robert H. Young

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The clinical and pathologic features of 15 primary urethral melanomas occurring in patients (nine women and six men) age 44 to 96 years (mean age, 73 yrs) are described. In the men the tumor involved the distal urethra. In eight women it involved the distal urethra, usually the meatus; both the distal and proximal urethra were involved in one woman. The tumors were typically polypoid and ranged from 0.8 to 6 cm (mean, 2.6 cm) in maximum dimension. A vertical growth phase was present in all tumors, with a prominent nodular component in seven of them. A radial growth phase was seen in nine tumors. The depth of invasion ranged from 2 to 17 mm. The tumors had diffuse, nested, storiform, or mixed growth patterns. The neoplastic cells typically had abundant eosinophilic cytoplasm, large nuclei with prominent nucleoli, and brisk mitotic activity. Melanin pigment was seen in 12 tumors but was conspicuous in only six. At the time of diagnosis, 13 tumors were confined to the urethra and two patients had lymph node metastasis. Nine patients died of disease 13 to 56 months after initial diagnosis and treatment, and one patient had a local recurrence at 4 years and subsequently died of sepsis 1 year later. Three patients were alive and well at 11 months, 23 months, and 7 years. One patient died at the time of the initial operation, and one died of a ruptured aortic aneurysm at 3 years without evidence of melanoma at autopsy. Primary malignant melanomas of the urethra, one fifth of which are amelanotic, must be included in the differential diagnosis of a number of primary neoplasms that involve the urethra, including transitional cell carcinoma, sarcomatoid carcinoma, and sarcomas. Conventional prognostic factors, such as depth of invasion or tumor stage, do not seem to play as important a role in predicting survival as the mucosal location and the nodular growth present frequently in these tumors.

Original languageEnglish (US)
Pages (from-to)785-796
Number of pages12
JournalAmerican Journal of Surgical Pathology
Volume24
Issue number6
DOIs
StatePublished - Jun 2000
Externally publishedYes

Fingerprint

Urethra
Melanoma
Neoplasms
Growth
Urethral Neoplasms
Aortic Rupture
Transitional Cell Carcinoma
Melanins
Sarcoma
Autopsy
Sepsis
Cytoplasm
Differential Diagnosis
Lymph Nodes
Neoplasm Metastasis
Carcinoma
Recurrence
Survival

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Primary malignant melanoma of the urethra a clinicopathologic analysis of 15 cases. / Oliva, Esther; Quinn, Timothy R.; Amin, Mahul; Eble, John N.; Epstein, Jonathan I.; Srigley, John R.; Young, Robert H.

In: American Journal of Surgical Pathology, Vol. 24, No. 6, 06.2000, p. 785-796.

Research output: Contribution to journalArticle

Oliva, Esther ; Quinn, Timothy R. ; Amin, Mahul ; Eble, John N. ; Epstein, Jonathan I. ; Srigley, John R. ; Young, Robert H. / Primary malignant melanoma of the urethra a clinicopathologic analysis of 15 cases. In: American Journal of Surgical Pathology. 2000 ; Vol. 24, No. 6. pp. 785-796.
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