Pro-healing potential of hemin: An inducer of heme oxygenase-1

Azad A. Ahanger, Shahid Prawez, Marie Dennis Leo, Kandaswamy Kathirvel, Dinesh Kumar, Surendra K. Tandan, Jitendra K. Malik

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Hemin induces heme oxygenase (HO), an enzyme which degrades heme in a rate-limiting manner and has an important role in cellular protection against oxidative stress and apoptosis. This HO inducer may be of potential therapeutic value in wound healing and inflammation. To identify the beneficial activity of HO vis a vis wound healing, hemin was used as inducer of HO in rats using a full-thickness cutaneous wound model. Hemin treatment increased cellular proliferation and collagen synthesis as evidenced by increase in wound contraction and hydroxyproline and glucosamine contents. mRNA expression of cytokines endorsed fast healing as was indicated by inhibition of pro-inflammatory cytokines such as ICAM-1 and TNF-α and up-regulation of anti-inflammatory cytokine IL-10.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalEuropean Journal of Pharmacology
Volume645
Issue number1-3
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

Fingerprint

Heme Oxygenase (Decyclizing)
Hemin
Heme Oxygenase-1
Cytokines
Wound Healing
Glucosamine
Hydroxyproline
Wounds and Injuries
Intercellular Adhesion Molecule-1
Heme
Interleukin-10
Oxidative Stress
Anti-Inflammatory Agents
Up-Regulation
Collagen
Cell Proliferation
Apoptosis
Inflammation
Messenger RNA
Skin

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Ahanger, A. A., Prawez, S., Leo, M. D., Kathirvel, K., Kumar, D., Tandan, S. K., & Malik, J. K. (2010). Pro-healing potential of hemin: An inducer of heme oxygenase-1. European Journal of Pharmacology, 645(1-3), 165-170. https://doi.org/10.1016/j.ejphar.2010.06.048

Pro-healing potential of hemin : An inducer of heme oxygenase-1. / Ahanger, Azad A.; Prawez, Shahid; Leo, Marie Dennis; Kathirvel, Kandaswamy; Kumar, Dinesh; Tandan, Surendra K.; Malik, Jitendra K.

In: European Journal of Pharmacology, Vol. 645, No. 1-3, 01.10.2010, p. 165-170.

Research output: Contribution to journalArticle

Ahanger, AA, Prawez, S, Leo, MD, Kathirvel, K, Kumar, D, Tandan, SK & Malik, JK 2010, 'Pro-healing potential of hemin: An inducer of heme oxygenase-1', European Journal of Pharmacology, vol. 645, no. 1-3, pp. 165-170. https://doi.org/10.1016/j.ejphar.2010.06.048
Ahanger, Azad A. ; Prawez, Shahid ; Leo, Marie Dennis ; Kathirvel, Kandaswamy ; Kumar, Dinesh ; Tandan, Surendra K. ; Malik, Jitendra K. / Pro-healing potential of hemin : An inducer of heme oxygenase-1. In: European Journal of Pharmacology. 2010 ; Vol. 645, No. 1-3. pp. 165-170.
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