Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats

Kristine Krajnak, Stacey Waugh, Roger Miller, Brent Baker, Kenneth Geronilla, Stephen Alway, Robert G. Cutlip

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Aging impairs the ability of muscle to adapt to exercise or injury. The goal of this study was to determine whether age-related changes in muscle adaptability could be the result of satellite cell apoptosis. Ten days after exposure to an injury protocol, estimates of edema in the exposed tibialis anterior muscles were higher in old (30 months) than young (3 months) rats, and isometric force levels were lower in old rats. Both young and old rats displayed an increase in MyoD labeling in the exposed muscle, indicating that injury induced satellite-cell activation. However, there were more MyoD-labeled cells that coexpressed the proapoptotic factor, Bax, in old than in young rats, suggesting that decrements in muscle recovery may be associated with an increase in satellite-cell apoptosis. Based on these findings we conclude that reducing satellite-cell apoptosis in aged animals may improve muscle recovery after injury.

Original languageEnglish (US)
Pages (from-to)720-730
Number of pages11
JournalMuscle and Nerve
Volume34
Issue number6
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

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Muscles
Wounds and Injuries
Apoptosis
Edema

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats. / Krajnak, Kristine; Waugh, Stacey; Miller, Roger; Baker, Brent; Geronilla, Kenneth; Alway, Stephen; Cutlip, Robert G.

In: Muscle and Nerve, Vol. 34, No. 6, 01.12.2006, p. 720-730.

Research output: Contribution to journalArticle

Krajnak, K, Waugh, S, Miller, R, Baker, B, Geronilla, K, Alway, S & Cutlip, RG 2006, 'Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats', Muscle and Nerve, vol. 34, no. 6, pp. 720-730. https://doi.org/10.1002/mus.20656
Krajnak, Kristine ; Waugh, Stacey ; Miller, Roger ; Baker, Brent ; Geronilla, Kenneth ; Alway, Stephen ; Cutlip, Robert G. / Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats. In: Muscle and Nerve. 2006 ; Vol. 34, No. 6. pp. 720-730.
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