Probable metronidazole induced serum sickness-like reaction in a paediatric patient

H. Z. VanCleave, A. C. Sanchez, Jay Lieberman, J. T. Ellenburg, W. A. Mabry

Research output: Contribution to journalArticle

Abstract

What is known and objective: Metronidazole (MTZ) is a commonly prescribed antibiotic and is generally well tolerated. To our knowledge, there has been only one case report linking MTZ with serum sickness-like reaction (SSLR). Case summary: We report a probable case of SSLR following the administration of MTZ in a paediatric patient. What is new and conclusion: Serum sickness-like reaction may be associated with MTZ therapy, and this type of adverse drug reaction may be underreported in the literature. A prior case report and evaluation with the Naranjo algorithm indicating a ‘probable’ adverse drug reaction provide evidence to support this conclusion.

Original languageEnglish (US)
Pages (from-to)736-738
Number of pages3
JournalJournal of Clinical Pharmacy and Therapeutics
Volume41
Issue number6
DOIs
StatePublished - Dec 1 2016

Fingerprint

Serum Sickness
Metronidazole
Pediatrics
Drug-Related Side Effects and Adverse Reactions
Anti-Bacterial Agents

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Probable metronidazole induced serum sickness-like reaction in a paediatric patient. / VanCleave, H. Z.; Sanchez, A. C.; Lieberman, Jay; Ellenburg, J. T.; Mabry, W. A.

In: Journal of Clinical Pharmacy and Therapeutics, Vol. 41, No. 6, 01.12.2016, p. 736-738.

Research output: Contribution to journalArticle

VanCleave, H. Z. ; Sanchez, A. C. ; Lieberman, Jay ; Ellenburg, J. T. ; Mabry, W. A. / Probable metronidazole induced serum sickness-like reaction in a paediatric patient. In: Journal of Clinical Pharmacy and Therapeutics. 2016 ; Vol. 41, No. 6. pp. 736-738.
@article{7eaf685b550a4710b3f6bc83da9bd002,
title = "Probable metronidazole induced serum sickness-like reaction in a paediatric patient",
abstract = "What is known and objective: Metronidazole (MTZ) is a commonly prescribed antibiotic and is generally well tolerated. To our knowledge, there has been only one case report linking MTZ with serum sickness-like reaction (SSLR). Case summary: We report a probable case of SSLR following the administration of MTZ in a paediatric patient. What is new and conclusion: Serum sickness-like reaction may be associated with MTZ therapy, and this type of adverse drug reaction may be underreported in the literature. A prior case report and evaluation with the Naranjo algorithm indicating a ‘probable’ adverse drug reaction provide evidence to support this conclusion.",
author = "VanCleave, {H. Z.} and Sanchez, {A. C.} and Jay Lieberman and Ellenburg, {J. T.} and Mabry, {W. A.}",
year = "2016",
month = "12",
day = "1",
doi = "10.1111/jcpt.12448",
language = "English (US)",
volume = "41",
pages = "736--738",
journal = "Journal of Clinical Pharmacy and Therapeutics",
issn = "0269-4727",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Probable metronidazole induced serum sickness-like reaction in a paediatric patient

AU - VanCleave, H. Z.

AU - Sanchez, A. C.

AU - Lieberman, Jay

AU - Ellenburg, J. T.

AU - Mabry, W. A.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - What is known and objective: Metronidazole (MTZ) is a commonly prescribed antibiotic and is generally well tolerated. To our knowledge, there has been only one case report linking MTZ with serum sickness-like reaction (SSLR). Case summary: We report a probable case of SSLR following the administration of MTZ in a paediatric patient. What is new and conclusion: Serum sickness-like reaction may be associated with MTZ therapy, and this type of adverse drug reaction may be underreported in the literature. A prior case report and evaluation with the Naranjo algorithm indicating a ‘probable’ adverse drug reaction provide evidence to support this conclusion.

AB - What is known and objective: Metronidazole (MTZ) is a commonly prescribed antibiotic and is generally well tolerated. To our knowledge, there has been only one case report linking MTZ with serum sickness-like reaction (SSLR). Case summary: We report a probable case of SSLR following the administration of MTZ in a paediatric patient. What is new and conclusion: Serum sickness-like reaction may be associated with MTZ therapy, and this type of adverse drug reaction may be underreported in the literature. A prior case report and evaluation with the Naranjo algorithm indicating a ‘probable’ adverse drug reaction provide evidence to support this conclusion.

UR - http://www.scopus.com/inward/record.url?scp=84992469962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992469962&partnerID=8YFLogxK

U2 - 10.1111/jcpt.12448

DO - 10.1111/jcpt.12448

M3 - Article

C2 - 27663456

AN - SCOPUS:84992469962

VL - 41

SP - 736

EP - 738

JO - Journal of Clinical Pharmacy and Therapeutics

JF - Journal of Clinical Pharmacy and Therapeutics

SN - 0269-4727

IS - 6

ER -