Profile of chronic hepatitis B virus in children in India

Experience with 116 children

Sanjaya Satapathy, S. Garg, R. Chauhan, V. Malhotra, P. Sakhuja, B. C. Sharma, S. K. Sarin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Hepatitis B virus (HBV) infection in children is mostly asymptomatic and therefore the disease burden is likely to be under appreciated. There is limited information on the profile of chronic HBV infection in children from the Indian subcontinent. Method: In 116 (male : female 89:27) children, aged <15 years, with persistent HBsAg positivity for more than 6 months, a clinical, biochemical, virological and histological assessment was carried out. Results: At presentation, 21.6% of children were symptomatic, with icterus in 12%. Features of decompensation such as ascites (7%) and gastrointestinal (GI) bleed (5%) were noted uncommonly. Five (4.3%) children had hepatocellular carcinoma (HCC) at presentation. Elevated alanine aminotransferase (ALT) was observed in 76% of subjects (median 61; range 14-815). A significantly higher proportion of children with hepatitis B early antigen (HbeAg) positive status had higher histological activity index (HAI) (84% vs 16%, P < 0.001) and fibrosis score (80% vs 20%, P = 0.007). A strong positive correlation was noted between aspartate aminotransferase (AST), ALT, HBV-DNA and histological severity of the disease (HAI ≥4, fibrosis ≥2). Median HBV-DNA levels were significantly higher in the HBeAg positive compared to the HBeAg negative group (25.6 vs 0.7 pg/mL, P = 0.004). Seventy-four percent of the mothers had evidence of past or present HBV infection. Conclusions: Majority of the children with chronic HBV infection are asymptomatic at presentation. HBeAg positive status reflects histologically more severe disease, and a higher level of HBV-DNA. Almost two-thirds of the children may have acquired their HBV infection perinataly.

Original languageEnglish (US)
Pages (from-to)1170-1176
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume21
Issue number7
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

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Chronic Hepatitis B
Hepatitis B virus
India
Virus Diseases
Hepatitis B e Antigens
Alanine Transaminase
DNA
Fibrosis
Hepatitis B Antigens
Asymptomatic Diseases
Hepatitis B Surface Antigens
Aspartate Aminotransferases
Jaundice
Ascites
Hepatocellular Carcinoma
Mothers

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Profile of chronic hepatitis B virus in children in India : Experience with 116 children. / Satapathy, Sanjaya; Garg, S.; Chauhan, R.; Malhotra, V.; Sakhuja, P.; Sharma, B. C.; Sarin, S. K.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 21, No. 7, 01.01.2006, p. 1170-1176.

Research output: Contribution to journalArticle

Satapathy, Sanjaya ; Garg, S. ; Chauhan, R. ; Malhotra, V. ; Sakhuja, P. ; Sharma, B. C. ; Sarin, S. K. / Profile of chronic hepatitis B virus in children in India : Experience with 116 children. In: Journal of Gastroenterology and Hepatology (Australia). 2006 ; Vol. 21, No. 7. pp. 1170-1176.
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