Prognostic factors and reporting of prostate carcinoma in radical prostatectomy and pelvic lymphadenectomy specimens

Jonathan I. Epstein, Mahul Amin, Liliane Boccon-Gibod, Lars Egevad, Peter A. Humphrey, Gregor Mikuz, Don Newling, Sten Nilsson, Wael Sakr, John R. Srigley, Thomas M. Wheeler, Rodolfo Montironi

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

This paper, based on the activity of the Morphology-Based Prognostic Factors Committee of the 2004 World Health Organization-sponsored International Consultation, describes various methods of handling radical prostatectomy specimens for both routine clinical use and research purposes. The correlation between radical prostatectomy findings and postoperative failure is discussed in detail. This includes issues relating to pelvic lymph node involvement, detected both at the time of frozen section and in permanent sections. Issues of seminal vesicle invasion, including its definition, routes of invasion and relationship to prognosis, are covered in detail. The definition, terminology and incidence of extra-prostatic extension are elucidated, along with its prognostic significance relating to location and extent. Margins of resection are covered in terms of their definition, the etiology, incidence and sites of positive margins, the use of frozen sections to assess the margins and the relationship between margin positivity and prognosis. Issues relating to grade within the radical prostatectomy specimen are covered in depth, including novel ways of reporting Gleason grade and the concept of tertiary Gleason patterns. Tumor volume, tumor location, vascular invasion and perineural invasion are the final variables discussed relating to the prognosis of radical prostatectomy specimens. The use of multivariate analysis to predict progression is discussed, together with proposed modifications to the TNM system. Finally, biomarkers to predict progression following radical prostatectomy are described, including DNA ploidy, microvessel density, Ki-67, neuroendocrine differentiation, p53, p21, p27, Bcl-2, Her-2/neu, E-cadherin, CD44, retinoblastoma proteins, apoptotic index, androgen receptor status, expression of prostate-specific antigen and prostatic-specific acid phosphatase and nuclear morphometry.

Original languageEnglish (US)
Pages (from-to)34-63
Number of pages30
JournalScandinavian Journal of Urology and Nephrology, Supplement
Volume39
Issue number216
DOIs
StatePublished - May 1 2005
Externally publishedYes

Fingerprint

Prostatectomy
Lymph Node Excision
Prostate
Carcinoma
Frozen Sections
Retinoblastoma Protein
Seminal Vesicles
Ploidies
Incidence
Androgen Receptors
Cadherins
Prostate-Specific Antigen
Microvessels
Tumor Burden
Terminology
Blood Vessels
Referral and Consultation
Multivariate Analysis
Biomarkers
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

Cite this

Prognostic factors and reporting of prostate carcinoma in radical prostatectomy and pelvic lymphadenectomy specimens. / Epstein, Jonathan I.; Amin, Mahul; Boccon-Gibod, Liliane; Egevad, Lars; Humphrey, Peter A.; Mikuz, Gregor; Newling, Don; Nilsson, Sten; Sakr, Wael; Srigley, John R.; Wheeler, Thomas M.; Montironi, Rodolfo.

In: Scandinavian Journal of Urology and Nephrology, Supplement, Vol. 39, No. 216, 01.05.2005, p. 34-63.

Research output: Contribution to journalArticle

Epstein, JI, Amin, M, Boccon-Gibod, L, Egevad, L, Humphrey, PA, Mikuz, G, Newling, D, Nilsson, S, Sakr, W, Srigley, JR, Wheeler, TM & Montironi, R 2005, 'Prognostic factors and reporting of prostate carcinoma in radical prostatectomy and pelvic lymphadenectomy specimens', Scandinavian Journal of Urology and Nephrology, Supplement, vol. 39, no. 216, pp. 34-63. https://doi.org/10.1080/03008880510030932
Epstein, Jonathan I. ; Amin, Mahul ; Boccon-Gibod, Liliane ; Egevad, Lars ; Humphrey, Peter A. ; Mikuz, Gregor ; Newling, Don ; Nilsson, Sten ; Sakr, Wael ; Srigley, John R. ; Wheeler, Thomas M. ; Montironi, Rodolfo. / Prognostic factors and reporting of prostate carcinoma in radical prostatectomy and pelvic lymphadenectomy specimens. In: Scandinavian Journal of Urology and Nephrology, Supplement. 2005 ; Vol. 39, No. 216. pp. 34-63.
@article{5331561029ac4f99b95a73619be2bfac,
title = "Prognostic factors and reporting of prostate carcinoma in radical prostatectomy and pelvic lymphadenectomy specimens",
abstract = "This paper, based on the activity of the Morphology-Based Prognostic Factors Committee of the 2004 World Health Organization-sponsored International Consultation, describes various methods of handling radical prostatectomy specimens for both routine clinical use and research purposes. The correlation between radical prostatectomy findings and postoperative failure is discussed in detail. This includes issues relating to pelvic lymph node involvement, detected both at the time of frozen section and in permanent sections. Issues of seminal vesicle invasion, including its definition, routes of invasion and relationship to prognosis, are covered in detail. The definition, terminology and incidence of extra-prostatic extension are elucidated, along with its prognostic significance relating to location and extent. Margins of resection are covered in terms of their definition, the etiology, incidence and sites of positive margins, the use of frozen sections to assess the margins and the relationship between margin positivity and prognosis. Issues relating to grade within the radical prostatectomy specimen are covered in depth, including novel ways of reporting Gleason grade and the concept of tertiary Gleason patterns. Tumor volume, tumor location, vascular invasion and perineural invasion are the final variables discussed relating to the prognosis of radical prostatectomy specimens. The use of multivariate analysis to predict progression is discussed, together with proposed modifications to the TNM system. Finally, biomarkers to predict progression following radical prostatectomy are described, including DNA ploidy, microvessel density, Ki-67, neuroendocrine differentiation, p53, p21, p27, Bcl-2, Her-2/neu, E-cadherin, CD44, retinoblastoma proteins, apoptotic index, androgen receptor status, expression of prostate-specific antigen and prostatic-specific acid phosphatase and nuclear morphometry.",
author = "Epstein, {Jonathan I.} and Mahul Amin and Liliane Boccon-Gibod and Lars Egevad and Humphrey, {Peter A.} and Gregor Mikuz and Don Newling and Sten Nilsson and Wael Sakr and Srigley, {John R.} and Wheeler, {Thomas M.} and Rodolfo Montironi",
year = "2005",
month = "5",
day = "1",
doi = "10.1080/03008880510030932",
language = "English (US)",
volume = "39",
pages = "34--63",
journal = "Scandinavian Journal of Urology and Nephrology, Supplement",
issn = "0300-8886",
publisher = "Taylor and Francis Ltd.",
number = "216",

}

TY - JOUR

T1 - Prognostic factors and reporting of prostate carcinoma in radical prostatectomy and pelvic lymphadenectomy specimens

AU - Epstein, Jonathan I.

AU - Amin, Mahul

AU - Boccon-Gibod, Liliane

AU - Egevad, Lars

AU - Humphrey, Peter A.

AU - Mikuz, Gregor

AU - Newling, Don

AU - Nilsson, Sten

AU - Sakr, Wael

AU - Srigley, John R.

AU - Wheeler, Thomas M.

AU - Montironi, Rodolfo

PY - 2005/5/1

Y1 - 2005/5/1

N2 - This paper, based on the activity of the Morphology-Based Prognostic Factors Committee of the 2004 World Health Organization-sponsored International Consultation, describes various methods of handling radical prostatectomy specimens for both routine clinical use and research purposes. The correlation between radical prostatectomy findings and postoperative failure is discussed in detail. This includes issues relating to pelvic lymph node involvement, detected both at the time of frozen section and in permanent sections. Issues of seminal vesicle invasion, including its definition, routes of invasion and relationship to prognosis, are covered in detail. The definition, terminology and incidence of extra-prostatic extension are elucidated, along with its prognostic significance relating to location and extent. Margins of resection are covered in terms of their definition, the etiology, incidence and sites of positive margins, the use of frozen sections to assess the margins and the relationship between margin positivity and prognosis. Issues relating to grade within the radical prostatectomy specimen are covered in depth, including novel ways of reporting Gleason grade and the concept of tertiary Gleason patterns. Tumor volume, tumor location, vascular invasion and perineural invasion are the final variables discussed relating to the prognosis of radical prostatectomy specimens. The use of multivariate analysis to predict progression is discussed, together with proposed modifications to the TNM system. Finally, biomarkers to predict progression following radical prostatectomy are described, including DNA ploidy, microvessel density, Ki-67, neuroendocrine differentiation, p53, p21, p27, Bcl-2, Her-2/neu, E-cadherin, CD44, retinoblastoma proteins, apoptotic index, androgen receptor status, expression of prostate-specific antigen and prostatic-specific acid phosphatase and nuclear morphometry.

AB - This paper, based on the activity of the Morphology-Based Prognostic Factors Committee of the 2004 World Health Organization-sponsored International Consultation, describes various methods of handling radical prostatectomy specimens for both routine clinical use and research purposes. The correlation between radical prostatectomy findings and postoperative failure is discussed in detail. This includes issues relating to pelvic lymph node involvement, detected both at the time of frozen section and in permanent sections. Issues of seminal vesicle invasion, including its definition, routes of invasion and relationship to prognosis, are covered in detail. The definition, terminology and incidence of extra-prostatic extension are elucidated, along with its prognostic significance relating to location and extent. Margins of resection are covered in terms of their definition, the etiology, incidence and sites of positive margins, the use of frozen sections to assess the margins and the relationship between margin positivity and prognosis. Issues relating to grade within the radical prostatectomy specimen are covered in depth, including novel ways of reporting Gleason grade and the concept of tertiary Gleason patterns. Tumor volume, tumor location, vascular invasion and perineural invasion are the final variables discussed relating to the prognosis of radical prostatectomy specimens. The use of multivariate analysis to predict progression is discussed, together with proposed modifications to the TNM system. Finally, biomarkers to predict progression following radical prostatectomy are described, including DNA ploidy, microvessel density, Ki-67, neuroendocrine differentiation, p53, p21, p27, Bcl-2, Her-2/neu, E-cadherin, CD44, retinoblastoma proteins, apoptotic index, androgen receptor status, expression of prostate-specific antigen and prostatic-specific acid phosphatase and nuclear morphometry.

UR - http://www.scopus.com/inward/record.url?scp=22144480321&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22144480321&partnerID=8YFLogxK

U2 - 10.1080/03008880510030932

DO - 10.1080/03008880510030932

M3 - Article

C2 - 16019758

AN - SCOPUS:22144480321

VL - 39

SP - 34

EP - 63

JO - Scandinavian Journal of Urology and Nephrology, Supplement

JF - Scandinavian Journal of Urology and Nephrology, Supplement

SN - 0300-8886

IS - 216

ER -