Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia

Sima Jeha, Frederick Behm, Deqing Pei, John T. Sandlund, Raul C. Ribeiro, Bassem I. Razzouk, Jeffrey E. Rubnitz, Nobuko Hijiya, Scott Howard, Cheng Cheng, Ching Hon Pui

Research output: Contribution to journalArticle

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Abstract

CD20 expression is associated with inferior survival in adults with acute lymphoblastic leukemia (ALL). We analyzed the prognostic impact of CD20 expression in 353 children with B-cell precursor ALL treated in 3 consecutive St Jude Total Therapy studies. CD20 expression (> 20%) was found in 169 patients (48%) and was more frequent in patients between 1 and 10 years of age than in those younger than 1 or older than 10 years (P = .001). None of 14 patients with MLL-AF4 expressed CD20. There was no association between CD20 expression and E2A-PBX, TEL-AML1, ploidy, white blood cell count at diagnosis, or sex. In contrast to the experience in adult ALL, our patients with CD20 expression tended to have a better treatment outcome than those without the expression: 5-year event-free survival 84% ± 2.9% versus 78% ± 3.1% (P = .08). These data suggest that CD20 expression is not associated with inferior outcome in pediatric patients treated with contemporary regimens.

Original languageEnglish (US)
Pages (from-to)3302-3304
Number of pages3
JournalBlood
Volume108
Issue number10
DOIs
StatePublished - Nov 15 2006
Externally publishedYes

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B-Lymphoid Precursor Cells
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cells
Private telephone exchanges
Pediatrics
Blood
Ploidies
Leukocyte Count
Disease-Free Survival
Survival

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Jeha, S., Behm, F., Pei, D., Sandlund, J. T., Ribeiro, R. C., Razzouk, B. I., ... Pui, C. H. (2006). Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia. Blood, 108(10), 3302-3304. https://doi.org/10.1182/blood-2006-04-016709

Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia. / Jeha, Sima; Behm, Frederick; Pei, Deqing; Sandlund, John T.; Ribeiro, Raul C.; Razzouk, Bassem I.; Rubnitz, Jeffrey E.; Hijiya, Nobuko; Howard, Scott; Cheng, Cheng; Pui, Ching Hon.

In: Blood, Vol. 108, No. 10, 15.11.2006, p. 3302-3304.

Research output: Contribution to journalArticle

Jeha, S, Behm, F, Pei, D, Sandlund, JT, Ribeiro, RC, Razzouk, BI, Rubnitz, JE, Hijiya, N, Howard, S, Cheng, C & Pui, CH 2006, 'Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia', Blood, vol. 108, no. 10, pp. 3302-3304. https://doi.org/10.1182/blood-2006-04-016709
Jeha S, Behm F, Pei D, Sandlund JT, Ribeiro RC, Razzouk BI et al. Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia. Blood. 2006 Nov 15;108(10):3302-3304. https://doi.org/10.1182/blood-2006-04-016709
Jeha, Sima ; Behm, Frederick ; Pei, Deqing ; Sandlund, John T. ; Ribeiro, Raul C. ; Razzouk, Bassem I. ; Rubnitz, Jeffrey E. ; Hijiya, Nobuko ; Howard, Scott ; Cheng, Cheng ; Pui, Ching Hon. / Prognostic significance of CD20 expression in childhood B-cell precursor acute lymphoblastic leukemia. In: Blood. 2006 ; Vol. 108, No. 10. pp. 3302-3304.
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