Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer

Vivian Labovsky, Leandro Marcelo Martinez, Kevin Mauro Davies, María de Luján Calcagno, Hernán García-Rivello, Alejandra Wernicke, Leonardo Feldman, Ayelén Matas, María Belén Giorello, Francisco Raúl Borzone, Hosoon Choi, Scott Howard, Norma Alejandra Chasseing

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator of nuclear factor kappa B ligand, stromal cell derived factor-1, interleukin-6, macrophage colony stimulating factor, chemokine (C-C motif) ligand-2 (CCL-2) and their receptors at significantly higher levels compared with non-neoplastic breast tissues. We evaluated the clinicopathological significance of these ligands and receptors in TEpC and spindle-shaped stromal cells, not associated with the vasculature, to determine their impact on prognosis of patients with early-stage breast cancer. Methods: We conducted immunohistochemical analyses of protein expression in primary tumors of patients with early breast cancer and analyzed their association with standard prognostic parameters and clinical outcomes, including local relapse, metastatic recurrence, disease-free survival (DFS), metastasis-free survival (MFS), and overall survival (OS). Results: Elevated levels of TRAIL-R3 and chemokine (C-C motif) receptor 2 (CCR-2) in TEpCs and OPG and CCL-2 in stromal cells were significantly associated with a higher risk of metastasis (p = 0.032, p = 0.003, p = 0.038, and p = 0.049; respectively). Moreover, high expression of TRAIL-R3 and CCR-2 in TEpCs was associated with shorter DFS, MFS, and OS. High TRAIL-R3 expression in TEpCs was an independent prognostic factor for DFS and OS, and high CCR-2 expression in these cells was an independent prognostic factor for MFS. Conclusions: High levels of TRAIL-R3 and CCR-2 expression in TEpCs identified patients with early breast cancer with poor outcomes.

Original languageEnglish (US)
Article number280
JournalBMC Cancer
Volume17
Issue number1
DOIs
StatePublished - Apr 18 2017

Fingerprint

Epithelial Cells
Breast Neoplasms
Survival
Stromal Cells
Neoplasms
Neoplasm Metastasis
Disease-Free Survival
Osteoprotegerin
Ligands
CCR Receptors
TNF-Related Apoptosis-Inducing Ligand Receptors
RANK Ligand
Chemokine CXCL12
Recurrence
Macrophage Colony-Stimulating Factor
Chemokine CCL2
Interleukin-6
Breast
Tumor Necrosis Factor-alpha
Apoptosis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Labovsky, V., Martinez, L. M., Davies, K. M., de Luján Calcagno, M., García-Rivello, H., Wernicke, A., ... Chasseing, N. A. (2017). Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer. BMC Cancer, 17(1), [280]. https://doi.org/10.1186/s12885-017-3259-8

Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer. / Labovsky, Vivian; Martinez, Leandro Marcelo; Davies, Kevin Mauro; de Luján Calcagno, María; García-Rivello, Hernán; Wernicke, Alejandra; Feldman, Leonardo; Matas, Ayelén; Giorello, María Belén; Borzone, Francisco Raúl; Choi, Hosoon; Howard, Scott; Chasseing, Norma Alejandra.

In: BMC Cancer, Vol. 17, No. 1, 280, 18.04.2017.

Research output: Contribution to journalArticle

Labovsky, V, Martinez, LM, Davies, KM, de Luján Calcagno, M, García-Rivello, H, Wernicke, A, Feldman, L, Matas, A, Giorello, MB, Borzone, FR, Choi, H, Howard, S & Chasseing, NA 2017, 'Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer', BMC Cancer, vol. 17, no. 1, 280. https://doi.org/10.1186/s12885-017-3259-8
Labovsky V, Martinez LM, Davies KM, de Luján Calcagno M, García-Rivello H, Wernicke A et al. Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer. BMC Cancer. 2017 Apr 18;17(1). 280. https://doi.org/10.1186/s12885-017-3259-8
Labovsky, Vivian ; Martinez, Leandro Marcelo ; Davies, Kevin Mauro ; de Luján Calcagno, María ; García-Rivello, Hernán ; Wernicke, Alejandra ; Feldman, Leonardo ; Matas, Ayelén ; Giorello, María Belén ; Borzone, Francisco Raúl ; Choi, Hosoon ; Howard, Scott ; Chasseing, Norma Alejandra. / Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer. In: BMC Cancer. 2017 ; Vol. 17, No. 1.
@article{25b4ab44dc2b47c0abed9eb5e04b2079,
title = "Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer",
abstract = "Background: Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator of nuclear factor kappa B ligand, stromal cell derived factor-1, interleukin-6, macrophage colony stimulating factor, chemokine (C-C motif) ligand-2 (CCL-2) and their receptors at significantly higher levels compared with non-neoplastic breast tissues. We evaluated the clinicopathological significance of these ligands and receptors in TEpC and spindle-shaped stromal cells, not associated with the vasculature, to determine their impact on prognosis of patients with early-stage breast cancer. Methods: We conducted immunohistochemical analyses of protein expression in primary tumors of patients with early breast cancer and analyzed their association with standard prognostic parameters and clinical outcomes, including local relapse, metastatic recurrence, disease-free survival (DFS), metastasis-free survival (MFS), and overall survival (OS). Results: Elevated levels of TRAIL-R3 and chemokine (C-C motif) receptor 2 (CCR-2) in TEpCs and OPG and CCL-2 in stromal cells were significantly associated with a higher risk of metastasis (p = 0.032, p = 0.003, p = 0.038, and p = 0.049; respectively). Moreover, high expression of TRAIL-R3 and CCR-2 in TEpCs was associated with shorter DFS, MFS, and OS. High TRAIL-R3 expression in TEpCs was an independent prognostic factor for DFS and OS, and high CCR-2 expression in these cells was an independent prognostic factor for MFS. Conclusions: High levels of TRAIL-R3 and CCR-2 expression in TEpCs identified patients with early breast cancer with poor outcomes.",
author = "Vivian Labovsky and Martinez, {Leandro Marcelo} and Davies, {Kevin Mauro} and {de Luj{\'a}n Calcagno}, Mar{\'i}a and Hern{\'a}n Garc{\'i}a-Rivello and Alejandra Wernicke and Leonardo Feldman and Ayel{\'e}n Matas and Giorello, {Mar{\'i}a Bel{\'e}n} and Borzone, {Francisco Ra{\'u}l} and Hosoon Choi and Scott Howard and Chasseing, {Norma Alejandra}",
year = "2017",
month = "4",
day = "18",
doi = "10.1186/s12885-017-3259-8",
language = "English (US)",
volume = "17",
journal = "BMC Cancer",
issn = "1471-2407",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer

AU - Labovsky, Vivian

AU - Martinez, Leandro Marcelo

AU - Davies, Kevin Mauro

AU - de Luján Calcagno, María

AU - García-Rivello, Hernán

AU - Wernicke, Alejandra

AU - Feldman, Leonardo

AU - Matas, Ayelén

AU - Giorello, María Belén

AU - Borzone, Francisco Raúl

AU - Choi, Hosoon

AU - Howard, Scott

AU - Chasseing, Norma Alejandra

PY - 2017/4/18

Y1 - 2017/4/18

N2 - Background: Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator of nuclear factor kappa B ligand, stromal cell derived factor-1, interleukin-6, macrophage colony stimulating factor, chemokine (C-C motif) ligand-2 (CCL-2) and their receptors at significantly higher levels compared with non-neoplastic breast tissues. We evaluated the clinicopathological significance of these ligands and receptors in TEpC and spindle-shaped stromal cells, not associated with the vasculature, to determine their impact on prognosis of patients with early-stage breast cancer. Methods: We conducted immunohistochemical analyses of protein expression in primary tumors of patients with early breast cancer and analyzed their association with standard prognostic parameters and clinical outcomes, including local relapse, metastatic recurrence, disease-free survival (DFS), metastasis-free survival (MFS), and overall survival (OS). Results: Elevated levels of TRAIL-R3 and chemokine (C-C motif) receptor 2 (CCR-2) in TEpCs and OPG and CCL-2 in stromal cells were significantly associated with a higher risk of metastasis (p = 0.032, p = 0.003, p = 0.038, and p = 0.049; respectively). Moreover, high expression of TRAIL-R3 and CCR-2 in TEpCs was associated with shorter DFS, MFS, and OS. High TRAIL-R3 expression in TEpCs was an independent prognostic factor for DFS and OS, and high CCR-2 expression in these cells was an independent prognostic factor for MFS. Conclusions: High levels of TRAIL-R3 and CCR-2 expression in TEpCs identified patients with early breast cancer with poor outcomes.

AB - Background: Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator of nuclear factor kappa B ligand, stromal cell derived factor-1, interleukin-6, macrophage colony stimulating factor, chemokine (C-C motif) ligand-2 (CCL-2) and their receptors at significantly higher levels compared with non-neoplastic breast tissues. We evaluated the clinicopathological significance of these ligands and receptors in TEpC and spindle-shaped stromal cells, not associated with the vasculature, to determine their impact on prognosis of patients with early-stage breast cancer. Methods: We conducted immunohistochemical analyses of protein expression in primary tumors of patients with early breast cancer and analyzed their association with standard prognostic parameters and clinical outcomes, including local relapse, metastatic recurrence, disease-free survival (DFS), metastasis-free survival (MFS), and overall survival (OS). Results: Elevated levels of TRAIL-R3 and chemokine (C-C motif) receptor 2 (CCR-2) in TEpCs and OPG and CCL-2 in stromal cells were significantly associated with a higher risk of metastasis (p = 0.032, p = 0.003, p = 0.038, and p = 0.049; respectively). Moreover, high expression of TRAIL-R3 and CCR-2 in TEpCs was associated with shorter DFS, MFS, and OS. High TRAIL-R3 expression in TEpCs was an independent prognostic factor for DFS and OS, and high CCR-2 expression in these cells was an independent prognostic factor for MFS. Conclusions: High levels of TRAIL-R3 and CCR-2 expression in TEpCs identified patients with early breast cancer with poor outcomes.

UR - http://www.scopus.com/inward/record.url?scp=85018527171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018527171&partnerID=8YFLogxK

U2 - 10.1186/s12885-017-3259-8

DO - 10.1186/s12885-017-3259-8

M3 - Article

VL - 17

JO - BMC Cancer

JF - BMC Cancer

SN - 1471-2407

IS - 1

M1 - 280

ER -