Prognostic value of usual gait speed in well-functioning older people - Results from the health, aging and body composition study

Matteo Cesari, Stephen B. Kritchevsky, Brenda W.H.J. Penninx, Barbara J. Nicklas, Eleanor M. Simonsick, Anne B. Newman, Frances Tylavsky, Jennifer S. Brach, Suzanne Satterfield, Douglas C. Bauer, Marjolein Visser, Susan M. Rubin, Tamara B. Harris, Marco Pahor

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons. DESIGN: Prospective cohort study. SETTING: Health, Aging and Body Composition Study. PARTICIPANTS: Three thousand forty-seven well-functioning older persons (mean age 74.2). MEASUREMENTS: Usual gait speed on a 6-m course was assessed at baseline. Participants were randomly divided into two groups to identify (Sample A; n = 2,031) and then validate (Sample B; n = 1,016) usual gait-speed cutpoints. Rates of persistent lower extremity limitation events (mean follow-up 4.9 years) were calculated according to gait speed in Sample A. A cutpoint (defining high- (<1 m/s) and low risk (≥1 m/s) groups) was identified based on persistent lower extremity limitation events. The predictive value of the identified cutpoints for major health-related events (persistent severe lower extremity limitation, death, and hospitalization) was evaluated in Sample B using Cox regression analyses. RESULTS: A graded response was seen between risk groups and health-related outcomes. Participants in the high-risk group had a higher risk of persistent lower extremity limitation (rate ratio (RR) = 2.20, 95% confidence interval (CI) = 1.76-2.74), persistent severe lower extremity limitation (RR = 2.29, 95% CI = 1.63-3.20), death (RR = 1.64, 95% CI = 1.14-2.37), and hospitalization (RR = 1.48, 95% CI = 1.02-2.13) than those in the low-risk group. CONCLUSION: Usual gait speed of less than 1 m/s identifies persons at high risk of health-related outcomes in well-functioning older people. Provision of a clinically meaningful cutpoint for usual gait speed may facilitate its use in clinical and research settings.

Original languageEnglish (US)
Pages (from-to)1675-1680
Number of pages6
JournalJournal of the American Geriatrics Society
Volume53
Issue number10
DOIs
StatePublished - Oct 1 2005

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Body Composition
Lower Extremity
Health
Confidence Intervals
Hospitalization
Walking Speed
Cohort Studies
Regression Analysis
Prospective Studies
Mortality
Research

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Cesari, M., Kritchevsky, S. B., Penninx, B. W. H. J., Nicklas, B. J., Simonsick, E. M., Newman, A. B., ... Pahor, M. (2005). Prognostic value of usual gait speed in well-functioning older people - Results from the health, aging and body composition study. Journal of the American Geriatrics Society, 53(10), 1675-1680. https://doi.org/10.1111/j.1532-5415.2005.53501.x

Prognostic value of usual gait speed in well-functioning older people - Results from the health, aging and body composition study. / Cesari, Matteo; Kritchevsky, Stephen B.; Penninx, Brenda W.H.J.; Nicklas, Barbara J.; Simonsick, Eleanor M.; Newman, Anne B.; Tylavsky, Frances; Brach, Jennifer S.; Satterfield, Suzanne; Bauer, Douglas C.; Visser, Marjolein; Rubin, Susan M.; Harris, Tamara B.; Pahor, Marco.

In: Journal of the American Geriatrics Society, Vol. 53, No. 10, 01.10.2005, p. 1675-1680.

Research output: Contribution to journalArticle

Cesari, M, Kritchevsky, SB, Penninx, BWHJ, Nicklas, BJ, Simonsick, EM, Newman, AB, Tylavsky, F, Brach, JS, Satterfield, S, Bauer, DC, Visser, M, Rubin, SM, Harris, TB & Pahor, M 2005, 'Prognostic value of usual gait speed in well-functioning older people - Results from the health, aging and body composition study', Journal of the American Geriatrics Society, vol. 53, no. 10, pp. 1675-1680. https://doi.org/10.1111/j.1532-5415.2005.53501.x
Cesari, Matteo ; Kritchevsky, Stephen B. ; Penninx, Brenda W.H.J. ; Nicklas, Barbara J. ; Simonsick, Eleanor M. ; Newman, Anne B. ; Tylavsky, Frances ; Brach, Jennifer S. ; Satterfield, Suzanne ; Bauer, Douglas C. ; Visser, Marjolein ; Rubin, Susan M. ; Harris, Tamara B. ; Pahor, Marco. / Prognostic value of usual gait speed in well-functioning older people - Results from the health, aging and body composition study. In: Journal of the American Geriatrics Society. 2005 ; Vol. 53, No. 10. pp. 1675-1680.
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abstract = "OBJECTIVES: To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons. DESIGN: Prospective cohort study. SETTING: Health, Aging and Body Composition Study. PARTICIPANTS: Three thousand forty-seven well-functioning older persons (mean age 74.2). MEASUREMENTS: Usual gait speed on a 6-m course was assessed at baseline. Participants were randomly divided into two groups to identify (Sample A; n = 2,031) and then validate (Sample B; n = 1,016) usual gait-speed cutpoints. Rates of persistent lower extremity limitation events (mean follow-up 4.9 years) were calculated according to gait speed in Sample A. A cutpoint (defining high- (<1 m/s) and low risk (≥1 m/s) groups) was identified based on persistent lower extremity limitation events. The predictive value of the identified cutpoints for major health-related events (persistent severe lower extremity limitation, death, and hospitalization) was evaluated in Sample B using Cox regression analyses. RESULTS: A graded response was seen between risk groups and health-related outcomes. Participants in the high-risk group had a higher risk of persistent lower extremity limitation (rate ratio (RR) = 2.20, 95{\%} confidence interval (CI) = 1.76-2.74), persistent severe lower extremity limitation (RR = 2.29, 95{\%} CI = 1.63-3.20), death (RR = 1.64, 95{\%} CI = 1.14-2.37), and hospitalization (RR = 1.48, 95{\%} CI = 1.02-2.13) than those in the low-risk group. CONCLUSION: Usual gait speed of less than 1 m/s identifies persons at high risk of health-related outcomes in well-functioning older people. Provision of a clinically meaningful cutpoint for usual gait speed may facilitate its use in clinical and research settings.",
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T1 - Prognostic value of usual gait speed in well-functioning older people - Results from the health, aging and body composition study

AU - Cesari, Matteo

AU - Kritchevsky, Stephen B.

AU - Penninx, Brenda W.H.J.

AU - Nicklas, Barbara J.

AU - Simonsick, Eleanor M.

AU - Newman, Anne B.

AU - Tylavsky, Frances

AU - Brach, Jennifer S.

AU - Satterfield, Suzanne

AU - Bauer, Douglas C.

AU - Visser, Marjolein

AU - Rubin, Susan M.

AU - Harris, Tamara B.

AU - Pahor, Marco

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N2 - OBJECTIVES: To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons. DESIGN: Prospective cohort study. SETTING: Health, Aging and Body Composition Study. PARTICIPANTS: Three thousand forty-seven well-functioning older persons (mean age 74.2). MEASUREMENTS: Usual gait speed on a 6-m course was assessed at baseline. Participants were randomly divided into two groups to identify (Sample A; n = 2,031) and then validate (Sample B; n = 1,016) usual gait-speed cutpoints. Rates of persistent lower extremity limitation events (mean follow-up 4.9 years) were calculated according to gait speed in Sample A. A cutpoint (defining high- (<1 m/s) and low risk (≥1 m/s) groups) was identified based on persistent lower extremity limitation events. The predictive value of the identified cutpoints for major health-related events (persistent severe lower extremity limitation, death, and hospitalization) was evaluated in Sample B using Cox regression analyses. RESULTS: A graded response was seen between risk groups and health-related outcomes. Participants in the high-risk group had a higher risk of persistent lower extremity limitation (rate ratio (RR) = 2.20, 95% confidence interval (CI) = 1.76-2.74), persistent severe lower extremity limitation (RR = 2.29, 95% CI = 1.63-3.20), death (RR = 1.64, 95% CI = 1.14-2.37), and hospitalization (RR = 1.48, 95% CI = 1.02-2.13) than those in the low-risk group. CONCLUSION: Usual gait speed of less than 1 m/s identifies persons at high risk of health-related outcomes in well-functioning older people. Provision of a clinically meaningful cutpoint for usual gait speed may facilitate its use in clinical and research settings.

AB - OBJECTIVES: To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons. DESIGN: Prospective cohort study. SETTING: Health, Aging and Body Composition Study. PARTICIPANTS: Three thousand forty-seven well-functioning older persons (mean age 74.2). MEASUREMENTS: Usual gait speed on a 6-m course was assessed at baseline. Participants were randomly divided into two groups to identify (Sample A; n = 2,031) and then validate (Sample B; n = 1,016) usual gait-speed cutpoints. Rates of persistent lower extremity limitation events (mean follow-up 4.9 years) were calculated according to gait speed in Sample A. A cutpoint (defining high- (<1 m/s) and low risk (≥1 m/s) groups) was identified based on persistent lower extremity limitation events. The predictive value of the identified cutpoints for major health-related events (persistent severe lower extremity limitation, death, and hospitalization) was evaluated in Sample B using Cox regression analyses. RESULTS: A graded response was seen between risk groups and health-related outcomes. Participants in the high-risk group had a higher risk of persistent lower extremity limitation (rate ratio (RR) = 2.20, 95% confidence interval (CI) = 1.76-2.74), persistent severe lower extremity limitation (RR = 2.29, 95% CI = 1.63-3.20), death (RR = 1.64, 95% CI = 1.14-2.37), and hospitalization (RR = 1.48, 95% CI = 1.02-2.13) than those in the low-risk group. CONCLUSION: Usual gait speed of less than 1 m/s identifies persons at high risk of health-related outcomes in well-functioning older people. Provision of a clinically meaningful cutpoint for usual gait speed may facilitate its use in clinical and research settings.

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