Progress and future aspects in genetics of human hypertension

Qi Zhao, Tanika N. Kelly, Changwei Li, Jiang He

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Hypertension has become a major global health burden due to its high prevalence and associated increase in risk of cardiovascular disease and premature death. It is well established that hypertension is determined by both genetic and environmental factors and their complex interactions. Recent large-scale meta-analyses of genome-wide association studies (GWAS) have successfully identified a total of 38 loci which achieved genome-wide significance (P < 5 × 10-8) for their association with blood pressure (BP). Although the heritability of BP explained by these loci is very limited, GWAS meta-analyses have elicited renewed optimism in hypertension genomics research, highlighting novel pathways influencing BP and elucidating genetic mechanisms underlying BP regulation. This review summarizes evolving progress in the rapidly moving field of hypertension genetics and highlights several promising approaches for dissecting the remaining heritability of BP. It also discusses the future translation of genetic findings to hypertension treatment and prevention.

Original languageEnglish (US)
Pages (from-to)676-686
Number of pages11
JournalCurrent Hypertension Reports
Volume15
Issue number6
DOIs
StatePublished - Dec 1 2013

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Medical Genetics
Blood Pressure
Hypertension
Genome-Wide Association Study
Meta-Analysis
Premature Mortality
Protein Biosynthesis
Genomics
Cardiovascular Diseases
Genome
Research

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Progress and future aspects in genetics of human hypertension. / Zhao, Qi; Kelly, Tanika N.; Li, Changwei; He, Jiang.

In: Current Hypertension Reports, Vol. 15, No. 6, 01.12.2013, p. 676-686.

Research output: Contribution to journalArticle

Zhao, Qi ; Kelly, Tanika N. ; Li, Changwei ; He, Jiang. / Progress and future aspects in genetics of human hypertension. In: Current Hypertension Reports. 2013 ; Vol. 15, No. 6. pp. 676-686.
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