Prolactinoma as the first manifestation of Gardner's syndrome

Geoffrey Goodin, M. Beth McCarville, Stephen N. Thibodeau, Stephen X. Skapek, Joseph D. Khoury, Sheri L. Spunt

Research output: Contribution to journalArticle

Abstract

Familial adenomatous polyposis (FAP) is an inherited condition causing numerous adenomatous colorectal polyps and a markedly elevated risk of colon cancer. FAP may be associated with various extracolonic manifestations such as desmoid fibromatosis and osteomas (termed Gardner's syndrome) and brain tumors, usually medulloblastoma or glioma [termed Brain Tumor Polyposis (BTP) syndrome type 2]. We describe a pediatric patient who initially presented with prolactinoma and later was found to have Gardner's syndrome. A germline mutation of the APC (adenomatous polyposis coli) gene was identified. Our case illustrates the association between prolactinoma and FAP, which may represent a rare subtype of Gardner's and BTP syndromes.

Original languageEnglish (US)
Pages (from-to)409-412
Number of pages4
JournalPediatric Blood and Cancer
Volume50
Issue number2
DOIs
StatePublished - Feb 1 2008

Fingerprint

Gardner Syndrome
Prolactinoma
Adenomatous Polyposis Coli
Brain Neoplasms
APC Genes
Osteoma
Aggressive Fibromatosis
Adenomatous Polyps
Medulloblastoma
Fibroma
Germ-Line Mutation
Glioma
Colonic Neoplasms
Pediatrics

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Goodin, G., McCarville, M. B., Thibodeau, S. N., Skapek, S. X., Khoury, J. D., & Spunt, S. L. (2008). Prolactinoma as the first manifestation of Gardner's syndrome. Pediatric Blood and Cancer, 50(2), 409-412. https://doi.org/10.1002/pbc.20985

Prolactinoma as the first manifestation of Gardner's syndrome. / Goodin, Geoffrey; McCarville, M. Beth; Thibodeau, Stephen N.; Skapek, Stephen X.; Khoury, Joseph D.; Spunt, Sheri L.

In: Pediatric Blood and Cancer, Vol. 50, No. 2, 01.02.2008, p. 409-412.

Research output: Contribution to journalArticle

Goodin, G, McCarville, MB, Thibodeau, SN, Skapek, SX, Khoury, JD & Spunt, SL 2008, 'Prolactinoma as the first manifestation of Gardner's syndrome', Pediatric Blood and Cancer, vol. 50, no. 2, pp. 409-412. https://doi.org/10.1002/pbc.20985
Goodin G, McCarville MB, Thibodeau SN, Skapek SX, Khoury JD, Spunt SL. Prolactinoma as the first manifestation of Gardner's syndrome. Pediatric Blood and Cancer. 2008 Feb 1;50(2):409-412. https://doi.org/10.1002/pbc.20985
Goodin, Geoffrey ; McCarville, M. Beth ; Thibodeau, Stephen N. ; Skapek, Stephen X. ; Khoury, Joseph D. ; Spunt, Sheri L. / Prolactinoma as the first manifestation of Gardner's syndrome. In: Pediatric Blood and Cancer. 2008 ; Vol. 50, No. 2. pp. 409-412.
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