Prophylactic antibiotic administration reduces sepsis and mortality in acute necrotizing pancreatitis

A meta-analysis

Virender Kumar Sharma, Colin Howden

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

Severe acute pancreatitis is frequently complicated by local and systemic infections resulting in substantial morbidity, mortality, and health care costs. Antibiotic prophylaxis may prevent some infections. We searched for randomized, controlled trials comparing antibiotic prophylaxis with no prophylaxis in patients with acute necrotizing pancreatitis (ANP). Only trials that used antibiotics that reach minimum inhibitory concentration (MIC) in necrotic pancreatic tissue were included. We calculated relative risk reduction (RRR), absolute risk reduction (ARR), and number needed to treat (NNT) for individual trials and pooled data. Antibiotic prophylaxis significantly reduced sepsis by 21.1% (NNT = 5) and mortality by 12.3% (NNT = 8) compared with no prophylaxis. There was also a nonsignificant trend toward a decrease in local pancreatic infections (ARR = 12%; NNT = 8). Antibiotic prophylaxis decreases sepsis and mortality in patients with ANP. All patients with ANP should be given prophylaxis with an antibiotic with proven efficacy in necrotic pancreatic tissue.

Original languageEnglish (US)
Pages (from-to)28-31
Number of pages4
JournalPancreas
Volume22
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

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Acute Necrotizing Pancreatitis
Numbers Needed To Treat
Antibiotic Prophylaxis
Meta-Analysis
Sepsis
Anti-Bacterial Agents
Mortality
Infection
Microbial Sensitivity Tests
Risk Reduction Behavior
Pancreatitis
Health Care Costs
Randomized Controlled Trials
Morbidity

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Endocrinology

Cite this

Prophylactic antibiotic administration reduces sepsis and mortality in acute necrotizing pancreatitis : A meta-analysis. / Sharma, Virender Kumar; Howden, Colin.

In: Pancreas, Vol. 22, No. 1, 2001, p. 28-31.

Research output: Contribution to journalArticle

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