Prostacyclin and prostaglandin E2 effects on adrenergic transmission in the kidney of anesthetized dog

H. Susic, Kafait Malik

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14 Citations (Scopus)

Abstract

The effect of prostaglandin E2 (PGE2) and prostacyclin (PGl2) on the renal venous output of the adrenergic transmitter and on the renal vasoconstriction produced by sympathetic nerve stimulation and by norepinephrine was studied in pentobarbital-anesthetized dog. Renal arterial infusion of either PGE2 or PGl2 (4 ng kg-1min-1) increased blood flow to the kidney and inhibited the vasoconstrictor response elicited by renal nerve stimulation (1-8 Hz) and by renal arterial injections of norpinephrine (0.06-0.5 μg). However, during infusion of either PGE2 or PGl2, the renal venous output of norepinephrine caused by nerve stimulation was not altered. In contrast, substance P (2 ng kg-1 min-1), which also increased the blood flow to the kidney, did not affect the renal vasoconstrictor response elicited by either adrenergic stimulus. These results suggest that PGE2 and PGl2 reduce the vasoconstrictor effect of sympathetic nerve stimulation in the canine kidney by acting on the vascular smooth muscle.

Original languageEnglish (US)
Pages (from-to)588-592
Number of pages5
JournalJournal of Pharmacology and Experimental Therapeutics
Volume218
Issue number3
StatePublished - Jan 1 1981

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Epoprostenol
Dinoprostone
Adrenergic Agents
Dogs
Kidney
Vasoconstrictor Agents
Norepinephrine
Pentobarbital
Substance P
Vasoconstriction
Vascular Smooth Muscle
Canidae
Injections

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

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abstract = "The effect of prostaglandin E2 (PGE2) and prostacyclin (PGl2) on the renal venous output of the adrenergic transmitter and on the renal vasoconstriction produced by sympathetic nerve stimulation and by norepinephrine was studied in pentobarbital-anesthetized dog. Renal arterial infusion of either PGE2 or PGl2 (4 ng kg-1min-1) increased blood flow to the kidney and inhibited the vasoconstrictor response elicited by renal nerve stimulation (1-8 Hz) and by renal arterial injections of norpinephrine (0.06-0.5 μg). However, during infusion of either PGE2 or PGl2, the renal venous output of norepinephrine caused by nerve stimulation was not altered. In contrast, substance P (2 ng kg-1 min-1), which also increased the blood flow to the kidney, did not affect the renal vasoconstrictor response elicited by either adrenergic stimulus. These results suggest that PGE2 and PGl2 reduce the vasoconstrictor effect of sympathetic nerve stimulation in the canine kidney by acting on the vascular smooth muscle.",
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AU - Malik, Kafait

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N2 - The effect of prostaglandin E2 (PGE2) and prostacyclin (PGl2) on the renal venous output of the adrenergic transmitter and on the renal vasoconstriction produced by sympathetic nerve stimulation and by norepinephrine was studied in pentobarbital-anesthetized dog. Renal arterial infusion of either PGE2 or PGl2 (4 ng kg-1min-1) increased blood flow to the kidney and inhibited the vasoconstrictor response elicited by renal nerve stimulation (1-8 Hz) and by renal arterial injections of norpinephrine (0.06-0.5 μg). However, during infusion of either PGE2 or PGl2, the renal venous output of norepinephrine caused by nerve stimulation was not altered. In contrast, substance P (2 ng kg-1 min-1), which also increased the blood flow to the kidney, did not affect the renal vasoconstrictor response elicited by either adrenergic stimulus. These results suggest that PGE2 and PGl2 reduce the vasoconstrictor effect of sympathetic nerve stimulation in the canine kidney by acting on the vascular smooth muscle.

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