Prostaglandins as determinants of vascular reactivity

J. C. McGiff, Kafait Malik, N. A. Terragno

Research output: Contribution to journalReview article

65 Citations (Scopus)

Abstract

Prostaglandins are primarily local or tissue hormones which have their effects at, or near to, the site of synthesis. Some blood vessels synthesize prostaglandins intramurally, where their local release influences vascular tone and reactivity. Endogenous prostaglandins (primarily prostaglandin E2 (PGE2)) participate in the regulation of vascular reactivity by opposing the vasoconstrictor and antinatriuretic actions of circulating pressor hormones; and by braking the release of norepinephrine from vasoconstrictor nerves. The proposal that one or more prostaglandins affect vascular reactivity is supported by the following observations: enhanced vascular reactivity to pressor stimuli occurs in organs with low basal rates of prostaglandin synthesis and after inhibition of prostaglandin synthetase in organs with high biosynthetic capacity; and exogenous PGE2 reversibly inhibits the vasoconstrictor activity of pressor stimuli.

Original languageEnglish (US)
Pages (from-to)2382-2387
Number of pages6
JournalFederation Proceedings
Volume35
Issue number12
StatePublished - 1976
Externally publishedYes

Fingerprint

Prostaglandins
Blood Vessels
Vasoconstrictor Agents
Dinoprostone
Hormones
Prostaglandin-Endoperoxide Synthases
Norepinephrine

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

McGiff, J. C., Malik, K., & Terragno, N. A. (1976). Prostaglandins as determinants of vascular reactivity. Federation Proceedings, 35(12), 2382-2387.

Prostaglandins as determinants of vascular reactivity. / McGiff, J. C.; Malik, Kafait; Terragno, N. A.

In: Federation Proceedings, Vol. 35, No. 12, 1976, p. 2382-2387.

Research output: Contribution to journalReview article

McGiff, JC, Malik, K & Terragno, NA 1976, 'Prostaglandins as determinants of vascular reactivity', Federation Proceedings, vol. 35, no. 12, pp. 2382-2387.
McGiff, J. C. ; Malik, Kafait ; Terragno, N. A. / Prostaglandins as determinants of vascular reactivity. In: Federation Proceedings. 1976 ; Vol. 35, No. 12. pp. 2382-2387.
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