Prostaglandins. Modulation of adrenergic nervous system

Research output: Contribution to journalReview article

65 Citations (Scopus)

Abstract

Prostaglandins (PGs) affect vascular tone by a direct action on the vascular smooth muscle and by influencing vascular reactivity to adrenergic stimuli and several vasoactive substances. Thus, in the isolated Tyrode's perfused rabbit renal, mesenteric and splenic vasculature PGE2 inhibited adrenergically induced vasoconstriction. Since the vasoconstrictor responses to renal nerve stimulation were enhanced by the blockade of PG synthesis and were reduced by stimulation of PG synthesis with arachidonic acid, this suggests that PGE2 functions as an inhibitory modulator of the adrenergic nervous system. However, our demonstration that PGE2 enhanced adrenergically induced vasoconstriction in the renal and mesenteric vasculature of the rat, but had opposite effects in the rat splenic vasculature indicates that the modulatory effect of PGE compounds on the adrenergic neuromuscular junction is species dependent and varies in different vascular beds within the same species. Prostaglandins, the release of which is evoked by several vasoactive substances including angiotensins, kinins, and adenine nucleotides, may also contribute to the regulation of vascular tone by either opposing or amplifying the vascular actions of vasoactive substances.

Original languageEnglish (US)
Pages (from-to)203-207
Number of pages5
JournalFederation Proceedings
Volume37
Issue number2
StatePublished - 1978

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Adrenergic Agents
Nervous System
Prostaglandins
Blood Vessels
Dinoprostone
Vasoconstriction
Kidney
Kinins
Adenine Nucleotides
Neuromuscular Junction
Angiotensins
Vasoconstrictor Agents
Prostaglandins E
Vascular Smooth Muscle
Arachidonic Acid
Rabbits

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Prostaglandins. Modulation of adrenergic nervous system. / Malik, Kafait.

In: Federation Proceedings, Vol. 37, No. 2, 1978, p. 203-207.

Research output: Contribution to journalReview article

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