Prostanoids modulate opioid-induced increases in cerebrospinal fluid vasopressin concentration

W. M. Armstead, R. Mirro, M. Shibata, Charles Leffler

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Topical dynorphin and β-endorphin produce increases in both prostanoid and vasopressin concentrations in cortical periarachnoid fluid of newborn pigs. The present study, in anesthetized piglets with cranial windows implanted, investigated the role of these prostanoids in the mediation of this vasopressin release by opioids. Topical prostaglandin (PG) I2 (100 ng/ml) increased pial arteriolar diameter from 145 ± 4 to 178 ± 4 μm and also increased cerebrospinal fluid (CSF) vasopressin from 1.1 ± 0.1 to 4.1 ± 0.5 μU/ml, but CSF vasopressin was not changed by PGE2, PGF(2α), and U- 46619. Therefore, it is possible that PGI2 causes the increase in CSF vasopressin produced by opioids. Consistent with this concept, indomethacin and aspirin blocked dynorphin- and β-endorphin-induced vasopressin release. The present data indicate that PGI2 contributes to opioid-induced changes in CSF vasopressin concentration and, thereby, to vasopressinergic contributions to opioid-induced cerebral vascular responses.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume263
Issue number6 32-6
StatePublished - Dec 1 1992

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Vasopressins
Opioid Analgesics
Prostaglandins
Cerebrospinal Fluid
Epoprostenol
Endorphins
Dynorphins
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Prostaglandins F
Dinoprostone
Indomethacin
Aspirin
Blood Vessels
Swine

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Prostanoids modulate opioid-induced increases in cerebrospinal fluid vasopressin concentration. / Armstead, W. M.; Mirro, R.; Shibata, M.; Leffler, Charles.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 263, No. 6 32-6, 01.12.1992.

Research output: Contribution to journalArticle

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