Prostate Specific Antigen in the Expressed Prostatic Fluid of Men with Benign Prostatic Hyperplasia and Prostate Carcinoma

Edward Kim, Norm D. Smith, John T. Grayhack

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: We tested the hypothesis that the histochemically demonstrated prostate specific antigen (PSA) content of prostate carcinoma cells does not necessarily reflect PSA production and secretion by evaluating expressed prostatic fluid. Materials and Methods: Expressed prostatic fluid and serum from 152 men with clinical benign prostatic hypertrophy (BPH), 132 with histologically proved BPH and 46 with prostate carcinoma were analyzed with the Hybritech PSA assay. Results: Expressed prostatic fluid PSA levels from carcinoma patients (median 1.70 mg./ml., mean 2.25) were significantly higher than in the histologically proved BPH group (median 1.28 mg./ml., mean 1.42, p less than 0.05). Conclusions: PSA concentration is increased in the expressed prostatic fluid of prostates of men with carcinoma compared to those with histological BPH. This finding may be a functional manifestation of a field change or paracrine effects within the prostate.

Original languageEnglish (US)
Pages (from-to)1802-1805
Number of pages4
JournalThe Journal of Urology
Volume154
Issue number5
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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Prostatic Hyperplasia
Prostate-Specific Antigen
Prostate
Carcinoma
Serum

All Science Journal Classification (ASJC) codes

  • Urology

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Prostate Specific Antigen in the Expressed Prostatic Fluid of Men with Benign Prostatic Hyperplasia and Prostate Carcinoma. / Kim, Edward; Smith, Norm D.; Grayhack, John T.

In: The Journal of Urology, Vol. 154, No. 5, 01.01.1995, p. 1802-1805.

Research output: Contribution to journalArticle

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