Prostate volume modifies the association between obesity and prostate cancer or high-grade prostatic intraepithelial neoplasia

Jay Fowke, Saundra S. Motley, Marcia Wills, Michael S. Cookson, Raoul S. Concepcion, Charles W. Eckstein, Sam S. Chang, Joseph A. Smith

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The relationship between obesity and prostate cancer remains unclear. We investigated the effect of prostate volume on the obesity and prostate cancer association. With a multi-centered, rapid-recruitment protocol, weight and body size measurements were collected prior to diagnosis, and medical charts were reviewed for pathology results (n = 420 controls, 119 high-grade prostatic intraepithelial neoplasia (PIN) cases, and 286 cancer cases (41% Gleason > 6). In multivariable logistic regression models adjusting for age, PSA levels and history, DRE results, and number of cores at biopsy, the association between BMI and cancer was restricted to men with a smaller prostate volume (volume < 40 cm3: ORBMI ≥ 30 = 2.17 (1.09, 4.32), p trend = 0.02; volume ≥ 40 cm3: ORBMI ≥ 30 = 0.77 (0.34, 1.77), ptrend = 0.17; pinteraction = 0.03). Similarly, the WHR and PIN association was significantly modified by prostate volume (volume < 40 cm3: OR(WHR: Tertile 3 vs. T1) = 3.76 (1.54, 9.21) (ptrend < 0.01); volume ≥ 40 m3: OR(WHR: T3 vs. T1) = 0.63 (0.32, 1.23) (ptrend = 0.17); pinteraction < 0.01). In conclusion, prostate volume acts as a modifier, and BMI and WHR are significantly associated with prostate cancer or PIN, respectively, in the absence of biopsy sampling error derived from obesity-related prostate enlargement.

Original languageEnglish (US)
Pages (from-to)375-384
Number of pages10
JournalCancer Causes and Control
Volume18
Issue number4
DOIs
StatePublished - May 1 2007
Externally publishedYes

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Prostatic Intraepithelial Neoplasia
Prostate
Prostatic Neoplasms
Obesity
Logistic Models
Biopsy
Selection Bias
Body Size
Neoplasms
History
Pathology
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Prostate volume modifies the association between obesity and prostate cancer or high-grade prostatic intraepithelial neoplasia. / Fowke, Jay; Motley, Saundra S.; Wills, Marcia; Cookson, Michael S.; Concepcion, Raoul S.; Eckstein, Charles W.; Chang, Sam S.; Smith, Joseph A.

In: Cancer Causes and Control, Vol. 18, No. 4, 01.05.2007, p. 375-384.

Research output: Contribution to journalArticle

Fowke, Jay ; Motley, Saundra S. ; Wills, Marcia ; Cookson, Michael S. ; Concepcion, Raoul S. ; Eckstein, Charles W. ; Chang, Sam S. ; Smith, Joseph A. / Prostate volume modifies the association between obesity and prostate cancer or high-grade prostatic intraepithelial neoplasia. In: Cancer Causes and Control. 2007 ; Vol. 18, No. 4. pp. 375-384.
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abstract = "The relationship between obesity and prostate cancer remains unclear. We investigated the effect of prostate volume on the obesity and prostate cancer association. With a multi-centered, rapid-recruitment protocol, weight and body size measurements were collected prior to diagnosis, and medical charts were reviewed for pathology results (n = 420 controls, 119 high-grade prostatic intraepithelial neoplasia (PIN) cases, and 286 cancer cases (41{\%} Gleason > 6). In multivariable logistic regression models adjusting for age, PSA levels and history, DRE results, and number of cores at biopsy, the association between BMI and cancer was restricted to men with a smaller prostate volume (volume < 40 cm3: ORBMI ≥ 30 = 2.17 (1.09, 4.32), p trend = 0.02; volume ≥ 40 cm3: ORBMI ≥ 30 = 0.77 (0.34, 1.77), ptrend = 0.17; pinteraction = 0.03). Similarly, the WHR and PIN association was significantly modified by prostate volume (volume < 40 cm3: OR(WHR: Tertile 3 vs. T1) = 3.76 (1.54, 9.21) (ptrend < 0.01); volume ≥ 40 m3: OR(WHR: T3 vs. T1) = 0.63 (0.32, 1.23) (ptrend = 0.17); pinteraction < 0.01). In conclusion, prostate volume acts as a modifier, and BMI and WHR are significantly associated with prostate cancer or PIN, respectively, in the absence of biopsy sampling error derived from obesity-related prostate enlargement.",
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