Prostatic levels of fatty acids and the histopathology of localized prostate cancer

Vincent L. Freeman, Mohsen Meydani, Sherri Yong, Joseph Pyle, Robert C. Flanigan, W Waters, Eva M. Wojcik

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Purpose: The consumption of various fatty acids has been associated with advanced stage and fatal prostate cancer. While numerous mechanisms have been postulated, to our knowledge there physiological data linking exposure and prognosis in humans are lacking. We examined prostatic levels of individual fatty acids in relation to the prevalence of histopathological characteristics associated with invasiveness and the risk of progression in 49 men undergoing radical prostatectomy for localized prostate cancer. Materials and Methods: Fatty acids were measured using capillary gas chromatography in fresh nonmalignant prostate tissue collected at surgery. Markers of invasiveness and increased risk of progression (Gleason sum 7 or greater, perineural invasion, anatomical or surgical margin involvement, extracapsular extension, seminal vesical involvement and stage T3 tumor) were evaluated separately. Each marker was dichotomized into a yes (case) and no (control) level with patients grouped accordingly. Mean concentrations were compared using the Wilcoxon rank sum test. Results: The percent of total prostatic polyunsaturated fat and polyunsaturated-to-saturated fat ratios were significantly lower in the presence of perineural invasion, seminal vesical involvement and stage T3 tumor (p = 0.02 to 0.049). α-Linolenic acid was significantly lower when tumor extended to an anatomical or surgical margin (p = 0.008). The ω-3 and ω-3-to-ω-6 fatty acid ratios were 1.5 to 3.3-fold lower in cases than in controls, reaching borderline significance in nearly all comparisons (p = 0.052 to 0.097). Saturated and monounsaturated fatty acids were not associated with the traits examined. Conclusions: These data suggest that polyunsaturated fatty acids and perhaps essential fatty acids in particular help to regulate prostate carcinogenesis in humans.

Original languageEnglish (US)
Pages (from-to)2168-2172
Number of pages5
JournalJournal of Urology
Volume164
Issue number6
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Prostatic Neoplasms
Fatty Acids
Nonparametric Statistics
Prostate
Urinary Bladder
Fats
Monounsaturated Fatty Acids
Neoplasms
Essential Fatty Acids
alpha-Linolenic Acid
Prostatectomy
Unsaturated Fatty Acids
Gas Chromatography
Carcinogenesis
Margins of Excision

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Freeman, V. L., Meydani, M., Yong, S., Pyle, J., Flanigan, R. C., Waters, W., & Wojcik, E. M. (2000). Prostatic levels of fatty acids and the histopathology of localized prostate cancer. Journal of Urology, 164(6), 2168-2172. https://doi.org/10.1016/S0022-5347(05)66991-1

Prostatic levels of fatty acids and the histopathology of localized prostate cancer. / Freeman, Vincent L.; Meydani, Mohsen; Yong, Sherri; Pyle, Joseph; Flanigan, Robert C.; Waters, W; Wojcik, Eva M.

In: Journal of Urology, Vol. 164, No. 6, 01.01.2000, p. 2168-2172.

Research output: Contribution to journalArticle

Freeman, VL, Meydani, M, Yong, S, Pyle, J, Flanigan, RC, Waters, W & Wojcik, EM 2000, 'Prostatic levels of fatty acids and the histopathology of localized prostate cancer', Journal of Urology, vol. 164, no. 6, pp. 2168-2172. https://doi.org/10.1016/S0022-5347(05)66991-1
Freeman, Vincent L. ; Meydani, Mohsen ; Yong, Sherri ; Pyle, Joseph ; Flanigan, Robert C. ; Waters, W ; Wojcik, Eva M. / Prostatic levels of fatty acids and the histopathology of localized prostate cancer. In: Journal of Urology. 2000 ; Vol. 164, No. 6. pp. 2168-2172.
@article{75e07fcb30cc45c7824c12598690e4e2,
title = "Prostatic levels of fatty acids and the histopathology of localized prostate cancer",
abstract = "Purpose: The consumption of various fatty acids has been associated with advanced stage and fatal prostate cancer. While numerous mechanisms have been postulated, to our knowledge there physiological data linking exposure and prognosis in humans are lacking. We examined prostatic levels of individual fatty acids in relation to the prevalence of histopathological characteristics associated with invasiveness and the risk of progression in 49 men undergoing radical prostatectomy for localized prostate cancer. Materials and Methods: Fatty acids were measured using capillary gas chromatography in fresh nonmalignant prostate tissue collected at surgery. Markers of invasiveness and increased risk of progression (Gleason sum 7 or greater, perineural invasion, anatomical or surgical margin involvement, extracapsular extension, seminal vesical involvement and stage T3 tumor) were evaluated separately. Each marker was dichotomized into a yes (case) and no (control) level with patients grouped accordingly. Mean concentrations were compared using the Wilcoxon rank sum test. Results: The percent of total prostatic polyunsaturated fat and polyunsaturated-to-saturated fat ratios were significantly lower in the presence of perineural invasion, seminal vesical involvement and stage T3 tumor (p = 0.02 to 0.049). α-Linolenic acid was significantly lower when tumor extended to an anatomical or surgical margin (p = 0.008). The ω-3 and ω-3-to-ω-6 fatty acid ratios were 1.5 to 3.3-fold lower in cases than in controls, reaching borderline significance in nearly all comparisons (p = 0.052 to 0.097). Saturated and monounsaturated fatty acids were not associated with the traits examined. Conclusions: These data suggest that polyunsaturated fatty acids and perhaps essential fatty acids in particular help to regulate prostate carcinogenesis in humans.",
author = "Freeman, {Vincent L.} and Mohsen Meydani and Sherri Yong and Joseph Pyle and Flanigan, {Robert C.} and W Waters and Wojcik, {Eva M.}",
year = "2000",
month = "1",
day = "1",
doi = "10.1016/S0022-5347(05)66991-1",
language = "English (US)",
volume = "164",
pages = "2168--2172",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Prostatic levels of fatty acids and the histopathology of localized prostate cancer

AU - Freeman, Vincent L.

AU - Meydani, Mohsen

AU - Yong, Sherri

AU - Pyle, Joseph

AU - Flanigan, Robert C.

AU - Waters, W

AU - Wojcik, Eva M.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Purpose: The consumption of various fatty acids has been associated with advanced stage and fatal prostate cancer. While numerous mechanisms have been postulated, to our knowledge there physiological data linking exposure and prognosis in humans are lacking. We examined prostatic levels of individual fatty acids in relation to the prevalence of histopathological characteristics associated with invasiveness and the risk of progression in 49 men undergoing radical prostatectomy for localized prostate cancer. Materials and Methods: Fatty acids were measured using capillary gas chromatography in fresh nonmalignant prostate tissue collected at surgery. Markers of invasiveness and increased risk of progression (Gleason sum 7 or greater, perineural invasion, anatomical or surgical margin involvement, extracapsular extension, seminal vesical involvement and stage T3 tumor) were evaluated separately. Each marker was dichotomized into a yes (case) and no (control) level with patients grouped accordingly. Mean concentrations were compared using the Wilcoxon rank sum test. Results: The percent of total prostatic polyunsaturated fat and polyunsaturated-to-saturated fat ratios were significantly lower in the presence of perineural invasion, seminal vesical involvement and stage T3 tumor (p = 0.02 to 0.049). α-Linolenic acid was significantly lower when tumor extended to an anatomical or surgical margin (p = 0.008). The ω-3 and ω-3-to-ω-6 fatty acid ratios were 1.5 to 3.3-fold lower in cases than in controls, reaching borderline significance in nearly all comparisons (p = 0.052 to 0.097). Saturated and monounsaturated fatty acids were not associated with the traits examined. Conclusions: These data suggest that polyunsaturated fatty acids and perhaps essential fatty acids in particular help to regulate prostate carcinogenesis in humans.

AB - Purpose: The consumption of various fatty acids has been associated with advanced stage and fatal prostate cancer. While numerous mechanisms have been postulated, to our knowledge there physiological data linking exposure and prognosis in humans are lacking. We examined prostatic levels of individual fatty acids in relation to the prevalence of histopathological characteristics associated with invasiveness and the risk of progression in 49 men undergoing radical prostatectomy for localized prostate cancer. Materials and Methods: Fatty acids were measured using capillary gas chromatography in fresh nonmalignant prostate tissue collected at surgery. Markers of invasiveness and increased risk of progression (Gleason sum 7 or greater, perineural invasion, anatomical or surgical margin involvement, extracapsular extension, seminal vesical involvement and stage T3 tumor) were evaluated separately. Each marker was dichotomized into a yes (case) and no (control) level with patients grouped accordingly. Mean concentrations were compared using the Wilcoxon rank sum test. Results: The percent of total prostatic polyunsaturated fat and polyunsaturated-to-saturated fat ratios were significantly lower in the presence of perineural invasion, seminal vesical involvement and stage T3 tumor (p = 0.02 to 0.049). α-Linolenic acid was significantly lower when tumor extended to an anatomical or surgical margin (p = 0.008). The ω-3 and ω-3-to-ω-6 fatty acid ratios were 1.5 to 3.3-fold lower in cases than in controls, reaching borderline significance in nearly all comparisons (p = 0.052 to 0.097). Saturated and monounsaturated fatty acids were not associated with the traits examined. Conclusions: These data suggest that polyunsaturated fatty acids and perhaps essential fatty acids in particular help to regulate prostate carcinogenesis in humans.

UR - http://www.scopus.com/inward/record.url?scp=0033764248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033764248&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(05)66991-1

DO - 10.1016/S0022-5347(05)66991-1

M3 - Article

VL - 164

SP - 2168

EP - 2172

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 6

ER -