Protease inhibition of natural killer (NK) and antibody-dependent cell-mediated cytoxicity (ADCC) activities

R. A. Floyd, C. Y. Kuo, T. J. Yoo, A. Song, Arnold Postlethwaite, C. Mainardi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The ability of protease inhibitors to modulate NK and ADCC cell activities was studied. NK and ADCC cell activities were suppressed by 1,10 phenanthroline (PHE), N-α-p-tosyl-l-lysine chloromethyl ketone (TLCK), l-1-tosylamide-2-phenylethylchoromethyl ketone (TPCK), N-benzoyl-dl-tyrosine ethyl ester (BTEE), and phenylmethylsulfonyl fluoride (PMSF). The effect of these protease inhibitors on ADCC was not mediated through the early phase of cytotoxicity involving Fc-receptor binding, since they failed to alter EoxA resetting of effector cells. The results suggest that an activated esterase system might play a role in the later phase of the cytotoxic mechanism by ADCC cells and perhaps NK cells.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalThe Journal of Laboratory and Clinical Medicine
Volume103
Issue number2
StatePublished - Jan 1 1984

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Antibody-Dependent Cell Cytotoxicity
Peptide Hydrolases
Antibodies
Protease Inhibitors
Phenylmethylsulfonyl Fluoride
Fc Receptors
Esterases
Cytotoxicity
Ketones
Natural Killer Cells

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Protease inhibition of natural killer (NK) and antibody-dependent cell-mediated cytoxicity (ADCC) activities. / Floyd, R. A.; Kuo, C. Y.; Yoo, T. J.; Song, A.; Postlethwaite, Arnold; Mainardi, C.

In: The Journal of Laboratory and Clinical Medicine, Vol. 103, No. 2, 01.01.1984, p. 215-222.

Research output: Contribution to journalArticle

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