Protection and restitution of gut barrier by probiotics

Nutritional and clinical implications

Radhakrishna Rao, Geetha Samak

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Probiotics are beneficial bacteria present in various dietary components and many of these colonize in the human and animal intestine. In the gut probiotics help the host by assisting in maintenance of normal mucosal homeostasis. Probiotics not only help maintain normal function of the gut mucosa, but also protect mucosa from injurious factors such as toxins, allergens and pathogens. The beneficial effect of probiotics is mediated by multiple mechanisms, including cytoprotection, cell proliferation, cell migration, resistance to apoptosis, synthesis of proteins and gene expression. One of the important cytoprotective effects of probiotics in the intestinal mucosa is to strengthen the epithelial tight junctions and preservation of mucosal barrier function. Probiotics not only enhance barrier function by inducing synthesis and assembly of tight junction proteins, but also by preventing disruption of tight junctions by injurious factors. Bioactive factors released by probiotics trigger activation of various cell signaling pathways that lead to strengthening of tight junctions and the barrier function. This article reviews and summarizes the current understanding of various probiotics that are involved in the protection of gut barrier function, highlights the cellular and molecular mechanisms involved in the protective effect and addresses the clinical implications of probiotic supplementation.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalCurrent Nutrition and Food Science
Volume9
Issue number2
DOIs
StatePublished - Jun 11 2013

Fingerprint

Probiotics
probiotics
digestive system
tight junctions
Tight Junctions
mucosa
Mucous Membrane
Tight Junction Proteins
synthesis
Cytoprotection
Intestinal Mucosa
intestinal mucosa
allergens
cell movement
Allergens
Intestines
Cell Movement
protective effect
cell proliferation
homeostasis

All Science Journal Classification (ASJC) codes

  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health
  • Food Science

Cite this

Protection and restitution of gut barrier by probiotics : Nutritional and clinical implications. / Rao, Radhakrishna; Samak, Geetha.

In: Current Nutrition and Food Science, Vol. 9, No. 2, 11.06.2013, p. 99-107.

Research output: Contribution to journalReview article

@article{827722c994f84b8abf2c6508fa1efc9c,
title = "Protection and restitution of gut barrier by probiotics: Nutritional and clinical implications",
abstract = "Probiotics are beneficial bacteria present in various dietary components and many of these colonize in the human and animal intestine. In the gut probiotics help the host by assisting in maintenance of normal mucosal homeostasis. Probiotics not only help maintain normal function of the gut mucosa, but also protect mucosa from injurious factors such as toxins, allergens and pathogens. The beneficial effect of probiotics is mediated by multiple mechanisms, including cytoprotection, cell proliferation, cell migration, resistance to apoptosis, synthesis of proteins and gene expression. One of the important cytoprotective effects of probiotics in the intestinal mucosa is to strengthen the epithelial tight junctions and preservation of mucosal barrier function. Probiotics not only enhance barrier function by inducing synthesis and assembly of tight junction proteins, but also by preventing disruption of tight junctions by injurious factors. Bioactive factors released by probiotics trigger activation of various cell signaling pathways that lead to strengthening of tight junctions and the barrier function. This article reviews and summarizes the current understanding of various probiotics that are involved in the protection of gut barrier function, highlights the cellular and molecular mechanisms involved in the protective effect and addresses the clinical implications of probiotic supplementation.",
author = "Radhakrishna Rao and Geetha Samak",
year = "2013",
month = "6",
day = "11",
doi = "10.2174/1573401311309020004",
language = "English (US)",
volume = "9",
pages = "99--107",
journal = "Current Nutrition and Food Science",
issn = "1573-4013",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - Protection and restitution of gut barrier by probiotics

T2 - Nutritional and clinical implications

AU - Rao, Radhakrishna

AU - Samak, Geetha

PY - 2013/6/11

Y1 - 2013/6/11

N2 - Probiotics are beneficial bacteria present in various dietary components and many of these colonize in the human and animal intestine. In the gut probiotics help the host by assisting in maintenance of normal mucosal homeostasis. Probiotics not only help maintain normal function of the gut mucosa, but also protect mucosa from injurious factors such as toxins, allergens and pathogens. The beneficial effect of probiotics is mediated by multiple mechanisms, including cytoprotection, cell proliferation, cell migration, resistance to apoptosis, synthesis of proteins and gene expression. One of the important cytoprotective effects of probiotics in the intestinal mucosa is to strengthen the epithelial tight junctions and preservation of mucosal barrier function. Probiotics not only enhance barrier function by inducing synthesis and assembly of tight junction proteins, but also by preventing disruption of tight junctions by injurious factors. Bioactive factors released by probiotics trigger activation of various cell signaling pathways that lead to strengthening of tight junctions and the barrier function. This article reviews and summarizes the current understanding of various probiotics that are involved in the protection of gut barrier function, highlights the cellular and molecular mechanisms involved in the protective effect and addresses the clinical implications of probiotic supplementation.

AB - Probiotics are beneficial bacteria present in various dietary components and many of these colonize in the human and animal intestine. In the gut probiotics help the host by assisting in maintenance of normal mucosal homeostasis. Probiotics not only help maintain normal function of the gut mucosa, but also protect mucosa from injurious factors such as toxins, allergens and pathogens. The beneficial effect of probiotics is mediated by multiple mechanisms, including cytoprotection, cell proliferation, cell migration, resistance to apoptosis, synthesis of proteins and gene expression. One of the important cytoprotective effects of probiotics in the intestinal mucosa is to strengthen the epithelial tight junctions and preservation of mucosal barrier function. Probiotics not only enhance barrier function by inducing synthesis and assembly of tight junction proteins, but also by preventing disruption of tight junctions by injurious factors. Bioactive factors released by probiotics trigger activation of various cell signaling pathways that lead to strengthening of tight junctions and the barrier function. This article reviews and summarizes the current understanding of various probiotics that are involved in the protection of gut barrier function, highlights the cellular and molecular mechanisms involved in the protective effect and addresses the clinical implications of probiotic supplementation.

UR - http://www.scopus.com/inward/record.url?scp=84878645943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878645943&partnerID=8YFLogxK

U2 - 10.2174/1573401311309020004

DO - 10.2174/1573401311309020004

M3 - Review article

VL - 9

SP - 99

EP - 107

JO - Current Nutrition and Food Science

JF - Current Nutrition and Food Science

SN - 1573-4013

IS - 2

ER -