Protection of ischemic preconditioning mediated by endogenous opioid peptides in rat hindquarters

F. W. Zhou, Y. J. Li, H. W. Deng

Research output: Contribution to journalArticle

Abstract

The mediation of endogenous opioid peptides in the protection of ischemic preconditioning in the rat hindquarters was investigated. Rat hindquarters were subjected to 2 h of ischemia, and endothelium-dependent vasorelaxation to acetylcholine (ACh) was examined. Preconditioning induced by three cycles of 5 min aortic occlusion and 5 min blood reperfusion markedly reduced the impairment of vasodilator responses to ACh by long-term ischemia. This protective effect of preconditioning was abolished by naloxone (3 mg.kg-1). Similarly, pretreatment with morphine (300 μg.kg-1) also attenuated the impairment of vasodilator responses to ACh, and the vasoprotection of morphine was abolished by pretreatment with capsaicin (50 mg.kg-1) to deplete calcitonin gene-related peptide (CGRP). These results suggest that endogenous opioid peptides participate in the mediation of the vasoprotection of ischemic preconditioning, which may involve endogenous CGRP in the rat hindquarters.

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalChinese Journal of Pharmacology and Toxicology
Volume12
Issue number4
StatePublished - 1998
Externally publishedYes

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Ischemic Preconditioning
Opioid Peptides
Acetylcholine
Rats
Calcitonin Gene-Related Peptide
Vasodilator Agents
Morphine
Ischemia
Capsaicin
Naloxone
Vasodilation
Reperfusion
Endothelium
Blood

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Toxicology

Cite this

Protection of ischemic preconditioning mediated by endogenous opioid peptides in rat hindquarters. / Zhou, F. W.; Li, Y. J.; Deng, H. W.

In: Chinese Journal of Pharmacology and Toxicology, Vol. 12, No. 4, 1998, p. 249-252.

Research output: Contribution to journalArticle

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