Protective and autoimmune epitopes of streptococcal M proteins

Edwin H. Beachey, Michael Bronze, James Dale, Werner Kraus, Thomas Poirier, Susie Sargent

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Several rheumatogenic serotypes of streptococcal M protein have been shown to contain both protective and cardiac tissue crossreactive epitopes. By synthesizing peptides copying different regions of M protein polypeptides, we were able to localize the protective and heart crossreactive epitopes. Some epitopes are only opsonic, some are only crossreactive, whereas others are both opsonic and tissue crossreactive. Multivalency of vaccines can be obtained by synthesizing protective peptides of one M serotype in tandem with protective peptides of other M serotypes. Such hybrid peptides evoke protective immune responses against the related streptococci without evoking tissue crossreactive immunity.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalVaccine
Volume6
Issue number2
DOIs
StatePublished - Jan 1 1988

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epitopes
Epitopes
peptides
Peptides
serotypes
proteins
Streptococcus
Immunity
Vaccines
polypeptides
immunity
heart
immune response
vaccines
Serogroup
streptococcal M protein
Proteins
tissues
retinal S antigen peptide M

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Beachey, E. H., Bronze, M., Dale, J., Kraus, W., Poirier, T., & Sargent, S. (1988). Protective and autoimmune epitopes of streptococcal M proteins. Vaccine, 6(2), 192-196. https://doi.org/10.1016/S0264-410X(88)80027-6

Protective and autoimmune epitopes of streptococcal M proteins. / Beachey, Edwin H.; Bronze, Michael; Dale, James; Kraus, Werner; Poirier, Thomas; Sargent, Susie.

In: Vaccine, Vol. 6, No. 2, 01.01.1988, p. 192-196.

Research output: Contribution to journalArticle

Beachey, EH, Bronze, M, Dale, J, Kraus, W, Poirier, T & Sargent, S 1988, 'Protective and autoimmune epitopes of streptococcal M proteins', Vaccine, vol. 6, no. 2, pp. 192-196. https://doi.org/10.1016/S0264-410X(88)80027-6
Beachey EH, Bronze M, Dale J, Kraus W, Poirier T, Sargent S. Protective and autoimmune epitopes of streptococcal M proteins. Vaccine. 1988 Jan 1;6(2):192-196. https://doi.org/10.1016/S0264-410X(88)80027-6
Beachey, Edwin H. ; Bronze, Michael ; Dale, James ; Kraus, Werner ; Poirier, Thomas ; Sargent, Susie. / Protective and autoimmune epitopes of streptococcal M proteins. In: Vaccine. 1988 ; Vol. 6, No. 2. pp. 192-196.
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