Protective effect of Acorus calamus against acrylamide induced neurotoxicity

Pradeep Kumar Shukla, Vinay K. Khanna, M. M. Ali, R. R. Maurya, S. S. Handa, R. C. Srimal

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Exposure of rats to acrylamide (ACR) caused hind limb paralysis in 58% of the animals on day 10 and decreased behavioural parameters, namely distance travelled, ambulatory time, stereotypic time and basal stereotypic movements compared with the control group. These rats also had a decrease in the reduced glutathione (GSH) content and glutathione-S-transferase (GST) activity in the corpus striatum and an increase in striatal dopamine receptors, as evident by an increase in the binding of 3H-spiperone to striatal membranes. Treatment with the ethanol:water (1:1) extract of the rhizomes of Acorus calamus (AC-002) increased the GSH content and GST activity in the corpus striatum while insignificant changes were observed in other parameters. Rats treated with ACR and AC-002 in combination had a lower incidence of paralysis (18%) compared with those treated with ACR alone on day 10 of the experiment. The rats also showed a partial recovery in other behavioural parameters. The levels of GSH content and GST activity increased in the corpus striatum, while the dopamine receptors decreased compared with the ACR treated rats. The results suggest that the neurobehavioural changes produced by ACR may be prevented following treatment with Acorus calamus rhizomes.

Original languageEnglish (US)
Pages (from-to)256-260
Number of pages5
JournalPhytotherapy Research
Volume16
Issue number3
DOIs
StatePublished - May 30 2002

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Acorus
Corpus Striatum
Acrylamide
Glutathione Transferase
Rhizome
Dopamine Receptors
Paralysis
Spiperone
Glutathione
Ethanol
Extremities
Control Groups
Membranes
Water
Incidence

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Shukla, P. K., Khanna, V. K., Ali, M. M., Maurya, R. R., Handa, S. S., & Srimal, R. C. (2002). Protective effect of Acorus calamus against acrylamide induced neurotoxicity. Phytotherapy Research, 16(3), 256-260. https://doi.org/10.1002/ptr.854

Protective effect of Acorus calamus against acrylamide induced neurotoxicity. / Shukla, Pradeep Kumar; Khanna, Vinay K.; Ali, M. M.; Maurya, R. R.; Handa, S. S.; Srimal, R. C.

In: Phytotherapy Research, Vol. 16, No. 3, 30.05.2002, p. 256-260.

Research output: Contribution to journalArticle

Shukla, PK, Khanna, VK, Ali, MM, Maurya, RR, Handa, SS & Srimal, RC 2002, 'Protective effect of Acorus calamus against acrylamide induced neurotoxicity', Phytotherapy Research, vol. 16, no. 3, pp. 256-260. https://doi.org/10.1002/ptr.854
Shukla, Pradeep Kumar ; Khanna, Vinay K. ; Ali, M. M. ; Maurya, R. R. ; Handa, S. S. ; Srimal, R. C. / Protective effect of Acorus calamus against acrylamide induced neurotoxicity. In: Phytotherapy Research. 2002 ; Vol. 16, No. 3. pp. 256-260.
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