Protective effect of bilberry extract as a pretreatment on induced oral mucositis in hamsters

Mehdy Davarmanesh, Ramin Miri, Sara Haghnegahdar, Azade Andishe Tadbir, Nader Tanideh, Mohammad Ali Saghiri, Franklin Garcia-Godoy, Armen Asatourian

Research output: Contribution to journalArticle

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Abstract

Objective This study evaluated the effect of standardized bilberry extract containing anthocyanosides on chemotherapy-induced oral mucositis in hamsters. Study Design Twenty-four hamsters were randomly chosen and assigned to groups. Groups A and B were pretreated with deionized water, whereas group C was pretreated with bilberry extract daily for 7 days. Groups B and C underwent chemotherapy by intraperitoneal injections of 5-fluorouracil (days 4, 9, and 14); group A received normal saline. Potentiation of oral mucositis was achieved by scratching both cheek pouches of all animals with needles (days 5, 6, and 14). The pouches were histopathologically examined on day 17 after visual examination and blood sampling by cardiac puncture. Results The bilberry extract group showed significantly lower oral mucositis clinical and histopathologic scores (P <.05) and less percentile of mean daily weight reductions compared with animals receiving vehicle. Conclusions Frequent administration of bilberry extract had a protective effect on oral mucosal damage induced by 5-fluorouracil in an animal model.

Original languageEnglish (US)
Pages (from-to)702-708
Number of pages7
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume116
Issue number6
DOIs
StatePublished - Dec 1 2013

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Vaccinium myrtillus
Stomatitis
Cricetinae
Fluorouracil
Drug Therapy
Cheek
Intraperitoneal Injections
Punctures
Needles
Weight Loss
Animal Models
Water

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

Cite this

Davarmanesh, M., Miri, R., Haghnegahdar, S., Tadbir, A. A., Tanideh, N., Saghiri, M. A., ... Asatourian, A. (2013). Protective effect of bilberry extract as a pretreatment on induced oral mucositis in hamsters. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 116(6), 702-708. https://doi.org/10.1016/j.oooo.2013.07.004

Protective effect of bilberry extract as a pretreatment on induced oral mucositis in hamsters. / Davarmanesh, Mehdy; Miri, Ramin; Haghnegahdar, Sara; Tadbir, Azade Andishe; Tanideh, Nader; Saghiri, Mohammad Ali; Garcia-Godoy, Franklin; Asatourian, Armen.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 116, No. 6, 01.12.2013, p. 702-708.

Research output: Contribution to journalArticle

Davarmanesh, Mehdy ; Miri, Ramin ; Haghnegahdar, Sara ; Tadbir, Azade Andishe ; Tanideh, Nader ; Saghiri, Mohammad Ali ; Garcia-Godoy, Franklin ; Asatourian, Armen. / Protective effect of bilberry extract as a pretreatment on induced oral mucositis in hamsters. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2013 ; Vol. 116, No. 6. pp. 702-708.
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AB - Objective This study evaluated the effect of standardized bilberry extract containing anthocyanosides on chemotherapy-induced oral mucositis in hamsters. Study Design Twenty-four hamsters were randomly chosen and assigned to groups. Groups A and B were pretreated with deionized water, whereas group C was pretreated with bilberry extract daily for 7 days. Groups B and C underwent chemotherapy by intraperitoneal injections of 5-fluorouracil (days 4, 9, and 14); group A received normal saline. Potentiation of oral mucositis was achieved by scratching both cheek pouches of all animals with needles (days 5, 6, and 14). The pouches were histopathologically examined on day 17 after visual examination and blood sampling by cardiac puncture. Results The bilberry extract group showed significantly lower oral mucositis clinical and histopathologic scores (P <.05) and less percentile of mean daily weight reductions compared with animals receiving vehicle. Conclusions Frequent administration of bilberry extract had a protective effect on oral mucosal damage induced by 5-fluorouracil in an animal model.

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