Protective effect of curcumin against lead neurotoxicity in rat

Pradeep Kumar Shukla, Vinay K. Khanna, Mohd Y. Khan, Rikhab C. Srimal

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases. The present study has been undertaken to investigate the protective effect of curcumin against lead-induced neurotoxicity in rats. Exposure of rats to lead (50 mg/kg po) for 45 days caused an increase in lipid peroxidation (LPO) and a decrease in reduced glutathione (GSH) levels in cerebellum, corpus striatum, hippocampus and frontal cortex as compared with controls. Lead levels were significantly increased in these rats. Activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) decreased in all the brain regions following lead exposure. Interestingly, cotreatment with curcumin (100 mg/kg po) and lead (50 mg/kg po) for 45 days caused a significant decrease in LPO with concomitant decrease in lead levels in all the brain regions as compared with those treated with lead alone. A significant increase in reduced glutathione (GSH) levels, SOD and CAT activities was also observed in all the four brain regions in rats simultaneously treated with curcumin and lead. The results suggest that curcumin may prevent lead-induced neurotoxicity.

Original languageEnglish (US)
Pages (from-to)653-658
Number of pages6
JournalHuman and Experimental Toxicology
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2003
Externally publishedYes

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Curcumin
Rats
Brain
Catalase
Lipid Peroxidation
Superoxide Dismutase
Glutathione
Antioxidants
Lipids
Corpus Striatum
Curcuma
Frontal Lobe
Lead
Cerebellum
Hippocampus
Enzymes

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Protective effect of curcumin against lead neurotoxicity in rat. / Shukla, Pradeep Kumar; Khanna, Vinay K.; Khan, Mohd Y.; Srimal, Rikhab C.

In: Human and Experimental Toxicology, Vol. 22, No. 12, 01.12.2003, p. 653-658.

Research output: Contribution to journalArticle

Shukla, Pradeep Kumar ; Khanna, Vinay K. ; Khan, Mohd Y. ; Srimal, Rikhab C. / Protective effect of curcumin against lead neurotoxicity in rat. In: Human and Experimental Toxicology. 2003 ; Vol. 22, No. 12. pp. 653-658.
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