Protective effect of Dl-3- n –butylphthalide on recovery from cardiac arrest and resuscitation in rats

Le Zhang, Michelle Puchowicz, Joseph C. LaManna, Kui Xu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

In this study we investigated the effect of Dl-3- n -butylphthalide (NBP), a clinically used drug for stroke patients in China, on the recovery following cardiac arrest and resuscitation in rats. Male Wistar rats (3-month old) underwent cardiac arrest (12 min) and resuscitation. Rats were randomly assigned to the following groups: sham non-arrested group, vehicle group (vehicle-treated, 7 days before cardiac arrest and 4 days post-resuscitation), NBP pre-treated group (NBP-treated, 7 days before cardiac arrest), and NBP post-treated group (NBP-treated, 4 days postresuscitation). Overall survival rates and hippocampal neuronal counts were determined in each group at 4 days post-resuscitation. Results showed that NBP pre-treated group (80%) and NBP post-treated group (86%) had significantly higher survival rates compared to that of the vehicle group (50%). At 4 days of recovery, only about 20% of hippocampal neurons were preserved in the vehicle group compared to the sham non-arrested group. The hippocampal CA1 cell counts in the NBP pre-treated group and NBP post-treated group were significantly higher than the counts in the vehicle group, about 50–60% of the counts of non-arrested rats. The data suggest that NBP has both preventive and therapeutic effect on improving outcome following cardiac arrest and resuscitation, and NBP might be a potential early phase treatment for patients recovered from cardiac arrest and resuscitation.

Original languageEnglish (US)
Title of host publicationOxygen Transport to Tissue XXXVIII
EditorsDuane F. Bruley, Qingming Luo, Lin Z. Li, Hua Shi, David K. Harrison, Duane F. Bruley
PublisherSpringer New York LLC
Pages31-36
Number of pages6
ISBN (Print)9783319388083
DOIs
StatePublished - Jan 1 2016
Event43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015 - Wuhan, China
Duration: Jul 11 2015Jul 16 2015

Publication series

NameAdvances in Experimental Medicine and Biology
Volume923
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Other

Other43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015
CountryChina
CityWuhan
Period7/11/157/16/15

Fingerprint

Resuscitation
Heart Arrest
Rats
Recovery
3-n-butylphthalide
Survival Rate
Therapeutic Uses
Neurons
Wistar Rats
China

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Zhang, L., Puchowicz, M., LaManna, J. C., & Xu, K. (2016). Protective effect of Dl-3- n –butylphthalide on recovery from cardiac arrest and resuscitation in rats. In D. F. Bruley, Q. Luo, L. Z. Li, H. Shi, D. K. Harrison, & D. F. Bruley (Eds.), Oxygen Transport to Tissue XXXVIII (pp. 31-36). (Advances in Experimental Medicine and Biology; Vol. 923). Springer New York LLC. https://doi.org/10.1007/978-3-319-38810-6_4

Protective effect of Dl-3- n –butylphthalide on recovery from cardiac arrest and resuscitation in rats. / Zhang, Le; Puchowicz, Michelle; LaManna, Joseph C.; Xu, Kui.

Oxygen Transport to Tissue XXXVIII. ed. / Duane F. Bruley; Qingming Luo; Lin Z. Li; Hua Shi; David K. Harrison; Duane F. Bruley. Springer New York LLC, 2016. p. 31-36 (Advances in Experimental Medicine and Biology; Vol. 923).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhang, L, Puchowicz, M, LaManna, JC & Xu, K 2016, Protective effect of Dl-3- n –butylphthalide on recovery from cardiac arrest and resuscitation in rats. in DF Bruley, Q Luo, LZ Li, H Shi, DK Harrison & DF Bruley (eds), Oxygen Transport to Tissue XXXVIII. Advances in Experimental Medicine and Biology, vol. 923, Springer New York LLC, pp. 31-36, 43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015, Wuhan, China, 7/11/15. https://doi.org/10.1007/978-3-319-38810-6_4
Zhang L, Puchowicz M, LaManna JC, Xu K. Protective effect of Dl-3- n –butylphthalide on recovery from cardiac arrest and resuscitation in rats. In Bruley DF, Luo Q, Li LZ, Shi H, Harrison DK, Bruley DF, editors, Oxygen Transport to Tissue XXXVIII. Springer New York LLC. 2016. p. 31-36. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-38810-6_4
Zhang, Le ; Puchowicz, Michelle ; LaManna, Joseph C. ; Xu, Kui. / Protective effect of Dl-3- n –butylphthalide on recovery from cardiac arrest and resuscitation in rats. Oxygen Transport to Tissue XXXVIII. editor / Duane F. Bruley ; Qingming Luo ; Lin Z. Li ; Hua Shi ; David K. Harrison ; Duane F. Bruley. Springer New York LLC, 2016. pp. 31-36 (Advances in Experimental Medicine and Biology).
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